The Association Between Intraoperative Objective Neuromuscular Monitoring and Rocuronium Consumption During Laparoscopic Abdominal Surgery: A Single-Center Retrospective Analysis (腹腔鏡下腹部手術における筋弛緩モニター使用の有無とロクロニウム投与量の関連性を調べた研究:単一施設後ろ向き研究) 11

• 資料種別: 博士論文
• ISSN: 2168-8184
• タイトル: The Association Between Intraoperative Objective Neuromuscular Monitoring and Rocuronium Consumption During Laparoscopic Abdominal Surgery: A Single-Center Retrospective Analysis (腹腔鏡下腹部手術における筋弛緩モニター使用の有無とロクロニウム投与量の関連性を調べた研究:単一施設後ろ向き研究)
• 巻次・部編番号: 13 11
• 著者・編者: 鷹架, 健一
• 著者標目: 鷹架, 健一
• 出版年月日等: 2021-11
• 出版年（W3CDTF）: 2021-11
• タイトル（掲載誌）: Cureus
• 授与機関名: 旭川医科大学
• 授与年月日: 2022-03-25
• 授与年月日（W3CDTF）: 2022-03-25
• 報告番号: 甲第570号
• 学位: 博士（医学）
• 博論授与番号: 甲第570号
• 本文の言語コード: eng
• 件名標目: elderly patients; laparoscopic surgery; neuromuscular monitoring; rocuronium; sugammadex
• 対象利用者: 一般
• 一般注記: type:application/pdf; Background Rocuronium consumption with or without intraoperative objective neuromuscular monitoring in clinical settings of unrestricted use of sugammadex and neuromuscular monitoring has not been reported earlier. The study aimed to investigate the association between the use of intraoperative objective neuromuscular monitoring and rocuronium consumption in patients undergoing laparoscopic abdominal surgery. Methods Data were collected by reviewing electronic medical records of patients who received laparoscopic abdominal surgery under general anesthesia with rocuronium and reversal with sugammadex at a university teaching hospital between May 2017 and April 2018. A multivariate linear regression model was developed to compare the amount of rocuronium consumption (mg) per weight (kg) per hour (mg/kg/h) between the group in which intraoperative objective neuromuscular monitoring was used (NMM+ group) and the group in which intraoperative neuromuscular monitoring was not used (NMM- group). Additionally, we performed an interaction test. Results A total of 429 patients were evaluated, with 371 patients (86%) included in the NMM+ group and 58 patients (14%) in the NMM- group. Log-transformed rocuronium consumption between the NMM+ group and NMM- group was not significantly different (back-transformed β coefficients [95% CI]: 1.080 [0.951-1.226]; P = 0.23). Male sex and body mass index (BMI) were independent factors associated with 15% (0.853 [0.788-0.924]; P < 0.001) and 3% (for every 1 kg/m2 increase in BMI) (0.971 [0.963-0.979]; P < 0.001) decrease in intraoperative rocuronium consumption, respectively. A significant interaction was detected only between the use of neuromuscular monitoring and age ≥65 years (β: 0.803 [0.662-0.974]; P = 0.026). Conclusions Although the use of intraoperative objective neuromuscular monitoring was not an individual factor influencing intraoperative rocuronium consumption, this retrospective study demonstrated that the use of intraoperative neuromuscular monitoring reduced rocuronium consumption for approximately 20% of elderly patients (age ≥65 years) undergoing laparoscopic abdominal surgery.; identifier:PMID:34900450
• DOI: info:doi/10.7759/cureus.19245; https://doi.org/info:doi/10.7759/cureus.19245
• 国立国会図書館永続的識別子: info:ndljp/pid/12313451; https://dl.ndl.go.jp/pid/12313451
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-08-08T06:02:54+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20220325_K570
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp