本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。
博士論文
国立国会図書館館内限定公開
収録元データベースで確認する
国立国会図書館デジタルコレクション
デジタルデータあり
公開元のウェブサイトで確認する
DOI[info:doi/10.1186/s40780-020-00187-3]のデータに遷移します
Opioid therapy duration before naldemedine treatment is a significant independent risk of diarrhea: a retrospective cohort study
- 国立国会図書館永続的識別子
- info:ndljp/pid/12313680
国立国会図書館での利用に関する注記
資料に関する注記
一般注記:
- application/pdfBackground: The most common adverse event (AE) associated with opioid analgesics is opioid-induced constipation (OIC). Naldemedine (NAL...
書店で探す
障害者向け資料で読む
書店で探す
障害者向け資料で読む
書誌情報
この資料の詳細や典拠(同じ主題の資料を指すキーワード、著者名)等を確認できます。
デジタル
- 資料種別
- 博士論文
- 著者・編者
- Okamoto, Akiharu
- 著者標目
- 出版事項
- 出版年月日等
- 2022-03-25
- 出版年(W3CDTF)
- 2022-03-25
- 授与機関名
- 三重大学
- 授与年月日
- 2022-03-25
- 授与年月日(W3CDTF)
- 2022-03-25
- 報告番号
- 甲医学第2106号
- 学位
- 博士(医学)
- 博論授与番号
- 甲医学第2106号
- 本文の言語コード
- eng
- 著者別名
- 対象利用者
- 一般
- 一般注記
- application/pdfBackground: The most common adverse event (AE) associated with opioid analgesics is opioid-induced constipation (OIC). Naldemedine (NAL) is widely used for the treatment of OIC. However, diarrhea has been reported as the most common treatment-emergent AE of NAL, and little is known about the risk factors associated with the development of diarrhea during NAL administration. This study examined the risk factors for NAL-induced diarrhea via a retrospective chart review of hospitalized patients.Methods: The data of 101 hospitalized adult patients who received NAL for the first time for the treatment of OIC at Mie University Hospital between June 2017 and December 2018 were extracted from electronic medical records. According to the inclusion and exclusion criteria, 70 of the 101 patients were enrolled in this study. Diarrhea was defined as “diarrhea” on the medical record within 2 weeks of NAL administration. Univariate and multivariate analyses were performed to identify risk factors for the development of diarrhea in patients receiving NAL.Results: Twenty-two of the 70 patients enrolled (31%) developed diarrhea within 2 weeks of NAL administration. The median duration (range) of NAL treatment before diarrhea onset was 3 (1–12) days. Patients with diarrhea had a significantly longer duration of opioid therapy before NAL administration than patients without diarrhea (P=0.002). Multivariate logistic regression analysis indicated that the independent risk factors for the development of NALinduced diarrhea were NAL administration after more than 17 days of opioid therapy (odds ratio [OR]=7.539; P= 0.016) and pancreatic cancer (OR=6.217; P=0.025). In fact, the incidence of diarrhea in patients who were administered NAL within a day of opioid therapy was significantly lower than that in patients who were administered NAL after more than 17 days of opioid therapy (13% vs. 54%, P=0.030).Conclusions: These results suggested that a prolonged duration of opioid therapy prior to NAL initiation is associated with increased incidence of diarrhea.本文/Department of Pharmacy, Mie University Hospital, 2-174 Edobashi, Tsu, Mie 514-8507, Japan8p
- DOI
- info:doi/10.1186/s40780-020-00187-3
- 国立国会図書館永続的識別子
- info:ndljp/pid/12313680
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2022-08-08T06:02:54+09:00
- 作成日(W3CDTF)
- 2022-07-20
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション