並列タイトル等The administration of hepatocyte growth factor prevents total parenteral nutrition‑induced hepatocellular injury in a rat model
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Purpose: Total parenteral nutrition (TPN) sometimes induces parenteral nutrition-associated liver disease (PNALD). Hepatocyte growth factor (HGF) acts as a potent hepatocyte mitogen anti-inflammatory and antioxidant actions. We aimed to evaluate the effect of HGF on PNALD in a rat model of TPN.Methods: A catheter was placed in the right jugular vein for 7-day continuous TPN. All rats were divided into three groups: TPN alone (TPN group), TPN plus intravenous HGF at 0.3 mg/kg/day [TPN + HGF (low) group], and TPN plus HGF at 1.0 mg/kg/day [TPN + HGF (high) group]. On day 7, livers were harvested and the histology, inflammatory cytokines and apoptosis were evaluated.Results: Histologically, lipid droplets were apparent in the TPN group, but decreased in the TPN + HGF (low) and TPN + HGF (high) groups. The histological nonalcoholic fatty liver disease activity scores in the TPN + HGF (low) and TPN + HGF (high) groups were significantly lower than that in the TPN group (p < 0.01). There were no significant differences in the inflammatory cytokine levels of the three groups. The caspase-9 expression levels in the TPN + HGF (low) and TPN + HGF (high) groups were significantly decreased in comparison to that in the control group (p < 0.05).Conclusion: The intravenous administration of HGF attenuated hepatic steatosis induced by 7-day TPN dose dependently.Makoto Matsukubo, Keisuke Yano, Tatsuru Kaji, Koshiro Sugita, Shun Onishi, Toshio Harumatsu, Ayaka Nagano, Mayu Matsui, Masakazu Murakami, Koji Yamada, Waka Yamada, Mitsuru Muto, Kotaro Kumagai, Akio Ido, Satoshi IeiriThe administration of hepatocyte growth factor prevents total parenteral nutrition-induced hepatocellular injury in a rat modelPediatric Surgery International (2021) 37:353–361This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:https://doi.org/10.1007/s00383-020-04823-9
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