並列タイトル等瘢痕化する器質化肺炎は線維化性間質性肺炎と相関する - 臨床病理学的検討
授与機関名Nagasaki University (長崎大学)
一般注記Aims: The recent recognition of cicatricial organising pneumonia (ciOP) indicates that the ciOP may resemble or simulate fibrotic interstitial pneumonia; however, there has been great uncertainty regarding the affected populations, pathogenesis, clinical relevance and characteristics. In this study, we compared the characteristics of fibrotic interstitial pneumonia with and without ciOP.Methods and results: We enrolled 121 patients from the consultation archive whose pathological findings were fibrotic interstitial pneumonia and for whom follow-up clinical data were available. We reviewed these cases histopathologically and classified them according to whether or not they showed ciOP. We compared the clinicopathological features between the two groups. CiOP, histopathologically characterised by deposition of dense collagenous fibres within the alveolar space without destruction of the lung structure, was found in 48 patients (39.7%). None of the cases with ciOP experienced acute exacerbation during 12 months’ follow-up. The group with ciOP had more severe diffusion impairment but this, together with restrictive ventilatory impairment, improved significantly compared to the group without ciOP.Conclusion: CiOP is a histopathological finding commonly found in fibrotic interstitial pneumonia. It does not relate to acute exacerbation or decrease in pulmonary function.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1418号 学位授与年月日:令和4年3月18日
Author: Yoshiaki Zaizen, Kazuhiro Tabata, Yasuhiko Yamano, Reoto Takei, Kensuke Kataoka, Akira Shiraki, Koichi Nishimura, Kazuto Furuyama, Andrey Bychkov, Tomoaki Hoshino, Takeshi Johkoh, Yasuhiro Kondoh & Junya Fukuoka
Citation: Histopathology, 80(2), pp. 279-290; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18)
http://hdl.handle.net/10069/00041421
DOIinfo:doi/10.1111/his.14427
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受理日（W3CDTF）2022-10-11T11:55:44+09:00
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