並列タイトル等Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Background: Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. Materials and Methods: SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas. Results: SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not. Conclusion: SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.Oesophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract (1). There have been many studies of the effects of various biological factors on the malignant potential of ESCC. Sex-determining region Y-box 9 (SOX9) is an important transcriptional factor for the development and differentiation of cells and their organization (2). Recently, there have been reports of a correlation between SOX9 expression and clinical outcomes in some cancer types, including gastrointestinal tract cancer (3-9). The aims of this retrospective study were to examine the expression of SOX9 protein in surgical specimens from patients with ESCC treated with radical surgery and to evaluate whether such expression is useful for predicting their outcome.NAOTOMO HIGO, HIROSHI OKUMURA, YASUTO UCHIKADO, ITARU OMOTO, KEN SASAKI, YOSHIAKI KITA, DESAKI RYOSUKE, MASAHIRO NODA, TETSUHIRO OWAKI, SUMIYA ISHIGAMI and SHOJI NATSUGOEExpression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell CarcinomaIn Vivo 32: 835-838 (2018)https://doi.org/10.21873/invivo.11316
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