並列タイトル等ミャンマー小児～成人におけるデングウイルス初感染および再感染の急性期血中サイトカイン動態と臨床的アウトカムとの相関性検討，2017－2019年
授与機関名Nagasaki University (長崎大学)
一般注記The dengue virus (DENV) has been endemic in Myanmar since 1970, causing outbreaks every 2–3 years. DENV infection symptoms range from mild fever to lethal hemorrhage. Clinical biomarkers must be identified to facilitate patient risk stratification in the early stages of infection. We analyzed 45 cytokines and other factors in serum samples from the acute phase of DENV infection (within 3–5 days of symptom onset) from 167 patients in Yangon, Myanmar, between 2017 and 2019. All of the patients tested positive for serum DENV nonstructural protein 1 antigen (NS1 Ag); 78.4% and 62.9% were positive for immunoglobulin M (IgM) and G (IgG), respectively; and 18.0%, 19.8%, and 11.9% tested positive for serotypes 1, 3, and 4, respectively. Although the DENV-4 viral load was significantly higher than those of DENV-1 or DENV-3, disease severity was not associated with viral load or serotype. Significant correlations were identified between disease severity and CCL5, SCF, PDGF-BB, IL-10, and TNF-α levels; between NS1 Ag and SCF, CCL5, IFN-α, IL-1α, and IL-22 levels; between thrombocytopenia and IL-2, TNF-α, VEGF-D, and IL-6 levels; and between primary or secondary infection and IL-2, IL-6, IL-31, IL-12p70, and MIP-1β levels. These circulating factors may represent leading signatures in acute DENV infections, reflecting the clinical outcomes in the dengue endemic region, Myanmar.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1469号 学位授与年月日:令和4年9月16日
Author: Khine Mya Nwe, Mya Myat Ngwe Tun, Theingi Win Myat, Chris Fook Sheng Ng, Moh Moh Htun, Htin Lin, Nang Sarm Hom, Aung Min Soe, Annie Elong Ngono, Shinjiro Hamano, Kouichi Morita, Kyaw Zin Thant, Sujan Shresta, Hlaing Myat Thu, and Meng Ling Moi
Citation: Pathogens, 11(5), art.no. 558; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-09-16)
http://hdl.handle.net/10069/00041835
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