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博士論文
国立国会図書館館内限定公開
収録元データベースで確認する
国立国会図書館デジタルコレクション
デジタルデータあり(Spandidos Publications)
SPTLC3は非アルコール性脂肪性肝疾患患者の肝発癌に関連する
- 国立国会図書館永続的識別子
- info:ndljp/pid/12651739
- 資料種別
- 博士論文
- 著者
- 伊集院, 翔
- 出版者
- Spandidos Publications
- 出版年
- 2022-03-11
- 資料形態
- デジタル
- ページ数・大きさ等
- -
- 授与大学名・学位
- 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science
国立国会図書館での利用に関する注記
資料に関する注記
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- 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨The prevalence of non‑alcoholic fatty liver disease (NAFLD) is continuously increasing, with the proportion of patie...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- 伊集院, 翔
- 著者標目
- 出版年月日等
- 2022-03-11
- 出版年(W3CDTF)
- 2022-03-11
- 並列タイトル等
- Serine palmitoyltransferase long chain subunit 3 is associated with hepatocellular carcinoma in patients with NAFLD
- 授与機関名
- 鹿児島大学
- 授与年月日
- 2022-03-11
- 授与年月日(W3CDTF)
- 2022-03-11
- 報告番号
- 甲総研第637号
- 学位
- 博士(医学)Doctor of Philosophy in Medical Science
- 本文の言語コード
- eng
- NDC
- 対象利用者
- 一般
- 一般注記
- 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨The prevalence of non‑alcoholic fatty liver disease (NAFLD) is continuously increasing, with the proportion of patients with liver carcinogenesis due to non‑alcoholic steatohepatitis (NASH) rising accordingly. Although it is important to identify individuals with hepatic carcinogenesis among patients with NAFLD, useful biomarkers have not yet been established. Previously, in a mouse model of diabetes mellitus without genetic modifications, we reported that a high‑fat diet increases serine palmitoyltransferase long chain subunit 3 (SPTLC3) expression in liver tissue, accompanied by high frequency of liver carcinogenesis. Serine palmitoyltransferase (SPT) catalyzes the metabolism of fatty acids, particularly sphingolipid synthesis, and SPTLC3 has been identified as its catalytic subunit, but its role in liver disease is unclear. In the present study, the importance of SPTLC3 in NAFLD development was investigated. SPTLC3 mRNA expression was observed in a liver cancer cell line and in liver tissues from patients with NAFLD and liver cancer. In total, 99 patients with NAFLD (66 without hepatocellular carcinoma (HCC) and 33 with HCC were recruited, having been diagnosed by liver biopsy or imaging, along with 6 healthy volunteers (HVs). Serum was collected from patients and HVs, and SPTLC3 level was assessed by ELISA. SPTLC3 expression was higher in non‑cancerous compared with that in cancerous liver tissues. Serum SPTLC3 levels were negatively correlated with platelet count and positively correlated with hyaluronic acid levels, suggesting an association with liver fibrosis. Moreover, SPTLC3 levels were significantly higher in the HCC group than in the HV and NAFLD groups. Multivariate analysis of HCC‑related factors identified platelets, alanine transferase, albumin and SPTLC3 as independent factors associated with HCC. Furthermore, in patients with other chronic liver diseases (hepatitis B and C, and alcoholic liver disease), no significant differences in serum SPTLC3 levels were observed between patients with or without HCC. Thus, SPTLC3 expression increases specifically with the progression of NAFLD. Overall, the present results indicate that SPTLC3 may be involved in the development of liver carcinogenesis during NAFLD.Sho Ijuin, Kohei Oda, Seiichi Mawatari, Ohki Taniyama, Ai Toyodome, Haruka Sakae, Kazuaki Tabu, Kotaro Kumagai, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirofumi Uto, Akio IdoSerine palmitoyltransferase long chain subunit 3 is associated with hepatocellular carcinoma in patients with NAFLDMOLECULAR AND CLINICAL ONCOLOGY 16: 55, 2022https://doi.org/10.3892/mco.2021.2488
- 国立国会図書館永続的識別子
- info:ndljp/pid/12651739
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2023-03-02T11:18:11+09:00
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション