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博士論文
国立国会図書館館内限定公開
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Streptococcus mutansにおけるソルターゼA依存性表層タンパク質の網羅的性状解析
- 国立国会図書館永続的識別子
- info:ndljp/pid/12651924
- 資料種別
- 博士論文
- 著者
- 勝俣, 環
- 出版者
- Wiley
- 出版年
- 2022-03-11
- 資料形態
- デジタル
- ページ数・大きさ等
- -
- 授与大学名・学位
- 鹿児島大学,博士(歯学),Doctor of Philosophy in Dental Science
国立国会図書館での利用に関する注記
資料に関する注記
一般注記:
- 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Streptococcus mutans, a cariogenic pathogen, adheres to the tooth surface and forms a biofilm. Bacterial cell surfac...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- 勝俣, 環
- 著者標目
- 出版事項
- 出版年月日等
- 2022-03-11
- 出版年(W3CDTF)
- 2022-03-11
- 並列タイトル等
- Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans
- 授与機関名
- 鹿児島大学
- 授与年月日
- 2022-03-11
- 授与年月日(W3CDTF)
- 2022-03-11
- 報告番号
- 甲総研第641号
- 学位
- 博士(歯学)Doctor of Philosophy in Dental Science
- 本文の言語コード
- eng
- NDC
- 対象利用者
- 一般
- 一般注記
- 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Streptococcus mutans, a cariogenic pathogen, adheres to the tooth surface and forms a biofilm. Bacterial cell surface proteins are associated with adherence to substrates. Sortase A (SrtA) mediates the localization of proteins with an LPXTG motif-containing proteins to the cell surface by covalent binding to peptidoglycan. In S. mutans UA159, six SrtA-dependent proteins, SpaP, WapA, WapE, DexA, FruA, and GbpC, were identified. Although some of these proteins were characterized, a comprehensive analysis of the six proteins has not been reported. In this study, we constructed mutants deficient in each of these proteins and the SrtA-deficient mutant. The SrtA-deficient mutant showed drastically decreased binding to salivary components, biofilm formation, bacterial coaggregation activity, hydrophobicity, and cellular matrix binding (collagen type I, fibronectin, and laminin). The SpaP-deficient mutant showed significantly reduced binding to salivary components and partially increased coaggregation with Porphyromonas gingivalis, and decreased hydrophobicity, and collagen binding. The WapA-deficient mutant showed slightly decreased coaggregation with Fusobacterium nucleatum. Although the SrtA-deficient mutant showed drastically altered phenotypes, all SrtA-dependent protein-deficient mutants, except the SpaP-deficient mutant, did not show considerable alterations in binding to salivary components. These results indicate that the six proteins may coordinately contribute to these activities. In addition, using genomic data of 125 S. mutans strains, the amino acid sequences of each surface protein were compared and many variations were found among strains, which may affect the phenotype of cell surface proteins in S. mutans.This is the peer reviewed version of the following article:Tamaki Katsumata, Mi Nguyen-Tra Le, Miki Kawada-Matsuo, Yuri Taniguchi, Kazuhisa Ouhara, Yuichi Oogai, Masanobu Nakata, Noriyoshi Mizuno, Yoshihiro Nishitani, Hitoshi KomatsuzawaComprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutansMicrobiol Immunol. 2022;66:145–156,which has been published in final form at https://doi.org/10.1111/1348-0421.12958. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- 国立国会図書館永続的識別子
- info:ndljp/pid/12651924
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2023-03-02T11:18:12+09:00
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション