並列タイトル等慢性骨髄性白血病および消化管間質腫瘍(GIST)の日本人患者におけるダサチニブおよびイマチニブに関連する心毒性有害事象の比較
授与機関名Nagasaki University (長崎大学)
一般注記Background: Despite the beneficial effects ofBCR-ABL1tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML), they may also cause adverse events (AEs), especially cardiovascular toxicity. The incidence of TKI-induced AEs may vary among ethnic groups, and there is little specific information for Japanese patients.Methods and Results: Sixty-nine consecutive patients who were started on treatment with dasatinib (n=25) or imatinib (n=44) for CML or gastrointestinal stromal tumor (GIST) between December 2008 and December 2019 were retrospectively recruited to the study. We determined the prevalence of AEs through October 2020 and compared the incidence of AEs between the 2 drugs. Baseline characteristics were comparable between the 2 groups. However, compared with the imatinib-treated group, the dasatinib-treated group had a higher incidence of congestive heart failure (CHF; 20.0% vs. 2.3%; P=0.04), pleural effusion (48% vs. 20.5%; P=0.03), pericardial effusion (24% vs. 4.6%; P=0.02), QT prolongation (4 vs. 0 patients; P=0.02), and pulmonary hypertension (3 vs. 0 patients; P=0.04). In the dasatinib-treated group, CHF tended to be associated with tricuspid valve regurgitation pressure gradient, and pleural effusion was observed in all patients. All-cause mortality and other cardiovascular events did not differ significantly between the 2 groups.Conclusions: Cardiotoxic AEs occurred more frequently in Japanese patients with CML and GIST treated with dasatinib than imatinib.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1422号 学位授与年月日:令和4年3月18日
Author: Tetsufumi Motokawa,Satoshi Ikeda,Yuki Ueno,Masamichi Eguchi,Takako Minami,Hiroaki Kawano,Kazuma Kobayashi,Yoshitaka Imaizumi,Koji Maemura
Citation: Circulation Reports, 4(1), pp. 1-8; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18)
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