並列タイトル等新生血管加齢黄斑変性に対するtreat&extendレジメン中止後の再発
授与機関名Nagasaki University (長崎大学)
一般注記The appropriate timing of treatment cessation after treat and extend (TAE) regimen for age-related macular degeneration has not been established. This study aimed to investigate the incidence and risk factors of recurrence after cessation of the TAE regimen. We included patients who received and discontinued the TAE regimen, after extension of the treatment interval to ≥ 12 weeks. Forty-nine patients were included in the study. The estimated recurrence rates were 33% at 1 year and 48% at 2 years after treatment cessation, respectively. Good visual acuity at cessation and a large number of injections in the 6 months before cessation were significant risk factors. Higher chances of recurrence were associated with < 0.1 logarithm of the minimum angle of resolution (logMAR) at cessation (P < 0.002). Meanwhile, five patients with visual acuity ≥ 1.0 logMAR at cessation did not show recurrence. Among the 25 recurrences, two lines of vision loss were noted in only two cases after resumed treatment. This study confirmed the importance of the number of injections in reducing recurrence and the association between visual acuity and recurrence. Recurrence is generally well-controlled with resumed treatment.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1472号 学位授与年月日:令和4年12月7日
Author: Yuki Hirata, Akio Oishi, Yuki Maekawa, Eiko Tsuiki, Akira Machida, Junko Kurihara & Takashi Kitaoka
Citation: Scientific Reports, 12, art. no. 14768; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-12-07)
http://hdl.handle.net/10069/00041979
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