Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome

• 資料種別: 博士論文
• タイトル: Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome
• 著者・編者: Nakamura, Fumika; Sato, Yasushi; Okamoto, Koichi; Fujino, Yasuteru; Mitsui, Yasuhiro; Kagemoto, Kaizo; Kawaguchi, Tomoyuki; Miyamoto, Hiroshi; Muguruma, Naoki; Sonoda, Tomoko; Tsuneyama, Koichi; Takayama, Tetsuji
• 著者標目: Nakamura, Fumika; Sato, Yasushi; Okamoto, Koichi; Fujino, Yasuteru; Mitsui, Yasuhiro; Kagemoto, Kaizo; Kawaguchi, Tomoyuki; Miyamoto, Hiroshi; Muguruma, Naoki; Sonoda, Tomoko; Tsuneyama, Koichi; Takayama, Tetsuji
• 出版事項: Springer|Japanese Society of Gastroenterology
• 出版年月日等: 2022-02-23; 57 4
• 出版年（W3CDTF）: 2022-02-23
• 並列タイトル等: 鋸歯状ポリポーシス症候群におけるadenoma-carcinoma pathwayによる発癌; Adenoma-cancer pathway in SPS
• 授与機関名: 徳島大学
• 授与年月日: 2022-09-22
• 授与年月日（W3CDTF）: 2022-09-22
• 報告番号: 甲第3659号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: serrated polyposis syndrome; colorectal cancer; adenoma; sessile serrated lesion; adenoma–carcinoma pathway; serrated-neoplasia pathway
• 対象利用者: 一般
• 一般注記: Background: Although serrated polyposis syndrome (SPS) is associated with an increased colorectal cancer (CRC) risk, the carcinogenic mechanisms remain unknown. We investigated clinicopathological characteristics and genetic abnormalities in colorectal polyps and CRC to elucidate carcinogenic mechanisms in SPS.Methods: We retrospectively analyzed clinicopathological features of colorectal polyps in 44 SPS patients, and examined mutations of genes including APC, RAS, BRAF, and TP53, and microsatellite instability (MSI) in CRC tissues.Results: Of the 44 patients, 25 (56%) fulfilled WHO criterion 1, 11 (25%) fulfilled criterion 2, and 8 (18%) fulfilled both. A total of 956 polyps were observed; 642 (67%) hyperplastic polyps (HP), 204 (21%) sessile serrated lesions (SSL), 10 (1%) traditional serrated adenoma (TSA), and 100 (11%) adenomas. The median numbers of polyps (/patient) were 10.5 (IQR 2.75-23) HPs, 4.0 (2.0-6.0) SSLs, 0 (0-0) TSA, and 1 (0-3.3) adenoma. SSL and HP located preferentially in the proximal and distal colon respectively. Twenty-two CRCs were found in 18 patients. Based on the histological coexistence of SSL/TSA, BRAF mutation and MSI, 5 CRCs (26%) were classified as serrated-neoplasia pathway. Conversely, based on the coexistence of adenoma, APC/RAS and TP53 mutations, 11 CRCs (58%) were classified as adenoma-carcinoma pathway. The remaining 3 were unclassifiable. Most CRCs through adenoma-carcinoma pathway were located in the left-side colorectum and patients bearing those met criterion 2, characterized by many HP and advanced adenomas. Adenoma was a significant risk factor for CRC.Conclusions: Our results suggest that more than half of the CRCs, particularly those in the left-side colorectum, developed through the adenoma-carcinoma pathway in SPS patients. Adenoma was a risk factor for CRCs, suggesting its importance in colorectal carcinogenesis.
• 国立国会図書館永続的識別子: info:ndljp/pid/12694228; https://dl.ndl.go.jp/pid/12694228
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2023-03-07T16:07:55+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/117614
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp