並列タイトル等Associations of the alpha-actinin three genotype with bone and muscle mass loss among middle-aged and older adults
学位博士（保健学）
Doctor of Philosophy in Health Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <−1.32 and <−1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05–8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss.Yoshiaki Taniguchi, Hyuma Makizako, Yuki Nakai, Yuto Kiuchi, Shoma Akaida, Mana Tateishi, Toshihiko Takenaka, Takuro Kubozono and Mitsuru OhishiAssociations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older AdultsJournal of Clinical Medicine 2022, 11, 6172https://doi.org/10.3390/jcm11206172
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2023-04-07T23:08:43+09:00
連携機関・データベース国立国会図書館 : 国立国会図書館デジタルコレクション