並列タイトル等酸化力・抗酸化力のバランスが重症患者の生命予後に関連する
授与機関名Nagasaki University (長崎大学)
一般注記It is well known that oxidative stress causes certain diseases and organ damage. However, roles of oxidative stress in the acute phase of critical patients remain to be elucidated. This study aimed to investigate the balance of oxidative and antioxidative system and to clarify the association between oxidative stress and mortality in critically ill patients. This cohort study enrolled 247 patients transported to our emergency department by ambulance. Blood was drawn on hospital arrival, and serum derivatives of reactive oxidant metabolites (dROMs, oxidative index) and biological antioxidant potential (BAP, antioxidative index) were measured. Modified ratio (MR) is also calculated as BAP/dROMs/7.51. There were 197 survivors and 50 non-survivors. In the nonsurvivors, dROMs were significantly lower (274 vs 311, p<0.01), BAP was significantly higher (2,853 vs 2,138, p<0.01), and MR was significantly higher (1.51 vs 0.92, p<0.01) compared to those in the survivors. The AUC of MR was similar to that for the APACHE II score. Contrary to our expectations, higher BAP and lower dROMs were observed on admission in non-survivors. This may suggest that the antioxidative system is more dominant in the acute phase of severe insults and that the balance toward a higher antioxidative system is associated with mortality.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1492号 学位授与年月日:令和5年3月1日
Author: Hiroo Izumino, Goro Tajima, Osamu Tasaki, Takamitsu Inokuma, Go Hatachi, Katsunori Takagi, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Shuntaro Sato, Takeshi Nagayasu
Citation: Journal of Clinical Biochemistry and Nutrition, 72(2), pp.157-164; 2023
identifier:Nagasaki University (長崎大学), 博士(医学) (2023-03-01)
http://hdl.handle.net/10069/00042225
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