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博士論文
国立国会図書館館内限定公開
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Addition of a vascular bundle accelerates bone union in femoral bone defects
- 国立国会図書館永続的識別子
- info:ndljp/pid/12864247
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一般注記:
- Background: The Masquelet method has become increasingly popular for the treatment of bone defects in recent years. In this method, an induced membran...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- 岡, 邦彦
- 著者標目
- 出版年月日等
- 2023-03-24
- 出版年(W3CDTF)
- 2023-03-24
- 並列タイトル等
- 血管束の導入が大腿骨骨欠損の骨癒合を促進する
- 授与機関名
- 香川大学
- 授与年月日
- 2023-03-24
- 授与年月日(W3CDTF)
- 2023-03-24
- 報告番号
- 甲第824号
- 学位
- 博士(医学)
- 本文の言語コード
- eng
- 著者別名
- 対象利用者
- 一般
- 一般注記
- Background: The Masquelet method has become increasingly popular for the treatment of bone defects in recent years. In this method, an induced membrane (IM) with abundant blood circulation, stem cells, and osteogenesis-promoting factors is formed by implanting bone cement during the first surgery. This IM stimulates bone formation in the bone defect after implantation of the bone graft during the second surgery. However, the Masquelet method requires two surgeries and thus a longer treatment period. In the present study, we investigated whether bone defects could be reconstructed in a single surgery by introducing a vascular bundle into the bone defect as an alternative to the IM, in addition to bone grafting.Methods: Thirty-six 12-week-old female Sprague-Dawley rats were used. After creating a 5-mm long bone defect in the femur, a mixture of autologous and artificial bone was grafted into the defect, and a saphenous arteriovenous vascular bundle was introduced. The animals were divided into three groups: the control group (bone defect only), the BG group (bone grafting only), and the BG + V group (bone grafting + vascular bundle introduction). After surgery, radiological and histological evaluations were performed to assess osteogenesis and angiogenesis in bone defects.Results: In the BG + V group, significant bone formation was observed in the bone defect on radiological and histological evaluations, and the amount of bone formation was significantly higher than that in the other two groups. Furthermore, cortical bone continuity was observed in many specimens in the BG + V group. On histological evaluation, the number of blood vessels was also significantly higher in the BG + V group than in the other two groups.Conclusion: Our results suggest that the introduction of a vascular bundle in addition to bone grafting can promote bone formation in bone defects and allow for complete bone defect reconstruction in a single surgery.
- 国立国会図書館永続的識別子
- info:ndljp/pid/12864247
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2023-05-05T22:12:36+09:00
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション