著者・編者Abdelghany, Lina Abdelhamid Abdelhamid
並列タイトル等ニカラベンは、癌細胞におけるBcl-2とポリ（ADP-リボース）グリコヒドロラーゼの発現レベルに応じて、異なる機序でプログラム細胞死を誘導する
授与機関名Nagasaki University (長崎大学)
一般注記The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear. In this study, we investigated the potential role and molecular mechanism of nicaraven on cancer cells. Using U937 lymphoma cells and HCT-8 colorectal cancer cells, we found that nicaraven moderately reduced the cell viability of both cells in a dose-dependent manner. Interestingly, nicaraven significantly induced apoptosis of U937 cells that are dominantly expressing Bcl-2 but induced PAR-dependent cell death (parthanatos) of HCT-8 cells that are highly expressing poly (ADP-ribose) glycohydrolase (PARG). Based on our data, nicaraven seems to induce programmed cell death through distinct mechanisms, according to the expression levels of Bcl-2 and PARG in cancer cells.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1528号 学位授与年月日:令和5年3月20日
Author: Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li
Citation: Translational Oncology, 26, art. no. 101548; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2023-03-20)
http://hdl.handle.net/10069/00042269
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