All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal

• 資料種別: 博士論文
• タイトル: All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal
• 著者・編者: Adachi, Yuichiro; Masuda, Masashi; Sakakibara, Iori; Uchida, Takayuki; Niida, Yuki; Mori, Yuki; Kamei, Yuki; Okumura, Yosuke; Ohminami, Hirokazu; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Nikawa, Takeshi; Taketani, Yutaka
• 著者標目: Adachi, Yuichiro; Masuda, Masashi; Sakakibara, Iori; Uchida, Takayuki; Niida, Yuki; Mori, Yuki; Kamei, Yuki; Okumura, Yosuke; Ohminami, Hirokazu; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Nikawa, Takeshi; Taketani, Yutaka
• 出版事項: Life Science Alliance
• 出版年月日等: 2022-03-22
• 出版年（W3CDTF）: 2022-03-22
• 並列タイトル等: 全トランスレチノイン酸はMAPKシグナル依存的なGADD34の増加を介して筋繊維タイプを変化させる; Increase of GADD34 expression in skeletal muscle by ATRA
• 授与機関名: 徳島大学
• 授与年月日: 2023-03-23
• 授与年月日（W3CDTF）: 2023-03-23
• 報告番号: 甲第3707号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: MAPK; mRNA stabilization; skeletal muscle type change; transcription; unfolded protein response
• 対象利用者: 一般
• 一般注記: All-trans retinoic acid (ATRA) increases the sensitivity to unfolded protein response in differentiating leukemic blasts. The downstream transcriptional factor of PERK, a major arm of unfolded protein response, regulates muscle differentiation. However, the role of growth arrest and DNA damage-inducible protein 34 (GADD34), one of the downstream factors of PERK, and the effects of ATRA on GADD34 expression in muscle remain unclear. In this study, we identified ATRA increased the GADD34 expression independent of the PERK signal in the gastrocnemius muscle of mice. ATRA up-regulated GADD34 expression through the transcriptional activation of GADD34 gene via inhibiting the interaction of homeobox Six1 and transcription co-repressor TLE3 with the MEF3-binding site on the GADD34 gene promoter in skeletal muscle. ATRA also inhibited the interaction of TTP, which induces mRNA degradation, with AU-rich element on GADD34 mRNA via p-38 MAPK, resulting in the instability of GADD34 mRNA. Overexpressed GADD34 in C2C12 cells changes the type of myosin heavy chain in myotubes. These results suggest ATRA increases GADD34 expression via transcriptional and post-transcriptional regulation, which changes muscle fiber type.
• 国立国会図書館永続的識別子: info:ndljp/pid/12912164; https://dl.ndl.go.jp/pid/12912164
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2023-07-08T03:42:35+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/117429
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp