並列タイトル等Development of a glycan repository and monosaccharide substitution matrix to strengthen the foundation of glycan informatics
一般注記In glycoinformatics, GlyTouCan, the international glycan structure repository, has been instrumental to properly manage the increasing numbers of glycan structures being researched in glycobiology. We have performed a major update on the GlyTouCan batch system to ensure consistency in registering its structures. In GlyTouCan, in order to search for glycan structures, currently only exact match searches have been implemented. However, the similarity of glycans could be better evaluated by creating a more versatile monosaccharide substitution matrix. Therefore, we have created a monosaccharide substitution matrix that takes into consideration not only their 3D structures but also their physicochemicalproperties. In addition to searching for glycan structures, this is the first attempt to quantify the similarity of monosaccharides. We have also evaluated this substitution matrix on the human data in GlyTouCan, thus demonstrating its validity and applicability.
コレクション(個別)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日(W3CDTF)2023-10-11T15:41:03+09:00
連携機関・データベース国立国会図書館 : 国立国会図書館デジタルコレクション