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博士論文
国立国会図書館館内限定公開
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国立国会図書館デジタルコレクション
デジタルデータあり(三重大学)
Risk Factors for Lung Function Decline in Pediatric Asthma under Treatment: A Retrospective, Multicenter, Observational Study
- 国立国会図書館永続的識別子
- info:ndljp/pid/13024279
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一般注記:
- application/pdfBackground: Childhood asthma is a major risk for low lung function in later adulthood, but what factors in asthma are associated with t...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- Yamada, Shingo
- 著者標目
- 出版事項
- 出版年月日等
- 2023-03-24
- 出版年(W3CDTF)
- 2023-03-24
- 授与機関名
- 三重大学
- 授与年月日
- 2023-03-24
- 授与年月日(W3CDTF)
- 2023-03-24
- 報告番号
- 甲医学第2178号
- 学位
- 博士(医学)
- 本文の言語コード
- eng
- 対象利用者
- 一般
- 一般注記
- application/pdfBackground: Childhood asthma is a major risk for low lung function in later adulthood, but what factors in asthma are associated with the poor lung function during childhood is not known. Objective: To identify clinical factors in children with asthma associated with low or declining lung function during the treatment. Methods: We enrolled children with asthma who had been treated throughout three age periods, i.e., 6–9, 10–12, and 13–15 years old, at seven specialized hospitals in Japan. Clinical information and lung function measurements were retrieved from the electronic chart systems. To characterize the lung function trajectories during each age period, we evaluated the forced expiratory volume 1 (FEV1) with % predicted values and individual changes by the slope (S) from linear regression. We defined four trajectory patterns: normal (Group N) and low (Group L), showing %FEV1 ≥80% or <80% throughout all three periods; upward (Group U) and downward (Group D), showing S ≥ 0 or S < 0%. Logistic regression analysis was performed to compare factors associated with the unfavorable (D/L) versus favorable (N/U) groups. Results: Among 273 eligible patients, 197 (72%) were classified into Group N (n = 150)/U (n = 47), while 76 (28%) were in Group D (n = 66)/L (n = 10). A history of poor asthma control, long-acting beta2 agonist use, and a lower height Z-score during 13–15 years were associated with an unfavorable outcome (Group D/L). Conversely, inhaled corticosteroid (ICS) use during 10–12 years and high-dose ICS use during 13–15 years were associated with a favorable outcome (Group N/U). Conclusion: We identified several factors that are associated with unfavorable lung function changes in pediatric asthma. Attention should be paid to the possible relationship between yearly changes in lung function and poor asthma control, use of ICS (and its dose) and use of LABA.本文/Allergy Center, National Hospital Organization Mie National Hospital, Tsu 514-0125, Japan15p
- 国立国会図書館永続的識別子
- info:ndljp/pid/13024279
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2023-10-11T15:41:06+09:00
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション