Antiglycative effect of ferulic acid
国立国会図書館館内限定公開
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DOI[10.24659/gsr.9.4_186]のデータに遷移します
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- 資料種別
- 記事
- 著者・編者
- Masayuki YagiChieko SakiyamaToshio Kitaba
- 出版事項
- 出版年月日等
- 2022-12-31
- 出版年（W3CDTF）
- 2022-12-31
- 並列タイトル等
- フェルラ酸の抗糖化作用
- タイトル（掲載誌）
- Glycative stress research
- 巻号年月日等（掲載誌）
- 9(4)
- 掲載巻
- 9(4)
- ISSN（掲載誌）
- 2188-3610
- ISSN-L（掲載誌）
- 2188-3610
- 本文の言語コード
- engjpn
- DOI
- 10.24659/gsr.9.4_186
- 国立国会図書館永続的識別子
- info:ndljp/pid/13120787
- コレクション（共通）
- コレクション（障害者向け資料：レベル1）
- コレクション（個別）
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- 収集根拠
- オンライン資料収集制度
- 受理日（W3CDTF）
- 2023-12-08T11:19:22+09:00
- 保存日（W3CDTF）
- 2023-05-20
- 記録形式（IMT）
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否（NDL）
- 可
- 掲載誌（URI）
- 掲載誌（国立国会図書館永続的識別子）
- info:ndljp/pid/13120786
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- コレクション（個別）
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否（NDL）
- 可
- 所蔵機関
- 国立国会図書館
- 請求記号
- Z63-D541
- 関連情報（国立国会図書館永続的識別子）
- info:ndljp/pid/13120787
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- 書誌ID（NDLBibID）
- 032834818
- 整理区分コード
- 632
- 要約等
- Glycative stress is one of the factors that cause aging and accelerates development of various diseases, including diabetes. Inhibition of glycative stress is referred to as anti-glycation. Anti-glycation includes suppression of postprandial hyperglycemia, suppression of glycative reaction, and decomposition and excretion of advanced glycation endproducts (AGEs). Inhibitory effects of AGE formation are recognized in various food materials such as herb teas, vegetables and fruits. It is reported that these food materials include many phenolic compounds that inhibit the formation of AGEs. Ferulic acid (FA) is a kind of phenolic compounds included in grains such as rice, wheat, fruits, vegetables, and other food materials. Bran (grain), in particular, includes a lot. FA is well known to be effective in inhibiting development of complications of diabetes or other neurotic diseases because of its anti-glycative / anti-inflammatory action. In our body, many kinds of AGEs are produced through many paths due to glycative stress, while there are many kinds of proteins that are glycated. On the other hand, reducing the function of proteins due to glycation is associated with the cross-linking formation induced by proteins changing into AGEs. The objective of this study was to evaluate the anti-diastatic effect of FA refined from rice bran. In this study, inhibitory effects of protein glycation reaction models such as human serum albumins (HSA), collagen and elastin, protein cross-linking formation by AGEs, and activity enhancement for oxidized protein hydrolase (OPH) were validated. As a result, it was clarified that FA inhibits the formation of fluorescent AGEs (F-AGEs) in all glycation reaction models. FA inhibited the formation of F-AGEs, pentosidine, CML, 3DG, GO, and MGO in the glycation reaction models of HSA-gulcose. In addition, FA also inhibited the formation of dimmer and trimer caused by the glycation of lysozyme. FA increased the OPH activation by a factor of 1.6. There is a possibility that anti-diastatication is associated with FA's usefulness for a variety of diseases.
- DOI
- 10.24659/gsr.9.4_186
- オンライン閲覧公開範囲
- インターネット公開
- 連携機関・データベース
- 科学技術振興機構 : J-STAGE
- 要約等
- Glycative stress is one of the factors that cause aging and accelerates development of various diseases, including diabetes. Inhibition of glycative stress is referred to as anti-glycation. Anti-glycation includes suppression of postprandial hyperglycemia, suppression of glycative reaction, and decomposition and excretion of advanced glycation endproducts (AGEs). Inhibitory effects of AGE formation are recognized in various food materials such as herb teas, vegetables and fruits. It is reported that these food materials include many phenolic compounds that inhibit the formation of AGEs. Ferulic acid (FA) is a kind of phenolic compounds included in grains such as rice, wheat, fruits, vegetables, and other food materials. Bran (grain), in particular, includes a lot. FA is well known to be effective in inhibiting development of complications of diabetes or other neurotic diseases because of its anti-glycative / anti-inflammatory action. In our body, many kinds of AGEs are produced through many paths due to glycative stress, while there are many kinds of proteins that are glycated. On the other hand, reducing the function of proteins due to glycation is associated with the cross-linking formation induced by proteins changing into AGEs. The objective of this study was to evaluate the anti-diastatic effect of FA refined from rice bran. In this study, inhibitory effects of protein glycation reaction models such as human serum albumins (HSA), collagen and elastin, protein cross-linking formation by AGEs, and activity enhancement for oxidized protein hydrolase (OPH) were validated. As a result, it was clarified that FA inhibits the formation of fluorescent AGEs (F-AGEs) in all glycation reaction models. FA inhibited the formation of F-AGEs, pentosidine, CML, 3DG, GO, and MGO in the glycation reaction models of HSA-gulcose. In addition, FA also inhibited the formation of dimmer and trimer caused by the glycation of lysozyme. FA increased the OPH activation by a factor of 1.6. There is a possibility that anti-diastatication is associated with FA's usefulness for a variety of diseases.
- DOI
- 10.24659/gsr.9.4_186
- 関連情報（URI）
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Japan Link Center雑誌記事索引データベース雑誌記事索引データベース
- 書誌ID（NDLBibID）
- 03283481813120787