シリンジ分注したω3系脂肪乳剤は気密性を保持し冷所保存すべきである: 貴重な未承認脂肪乳剤を有効かつ安全に供給するために

• 資料種別: 博士論文
• タイトル: シリンジ分注したω3系脂肪乳剤は気密性を保持し冷所保存すべきである: 貴重な未承認脂肪乳剤を有効かつ安全に供給するために
• 著者・編者: 瀬戸口, 誠
• 著者標目: 瀬戸口, 誠
• 出版事項: Wiley
• 出版年月日等: 2023-03-23
• 出版年（W3CDTF）: 2023-03-23
• 並列タイトル等: Syringe-dispensed omega-3 lipid injectable emulsions should be stored under airtight refrigeration: a proposal for the efficient supply of unapproved precious lipid resources
• 授与機関名: 鹿児島大学
• 授与年月日: 2023-03-23
• 授与年月日（W3CDTF）: 2023-03-23
• 報告番号: 甲総研第694号
• 学位: 博士(医学); Doctor of Philosophy in Medical Science
• 本文の言語コード: eng
• 件名標目: injectable lipid emulsions; intestinal failure; lipid peroxidation; malondialdehyde; parenteral nutrition
• 対象利用者: 一般
• 一般注記: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: Both fish-oil lipid injectable emulsion (FO-ILE) and mixed-oil lipid injectable emulsion (MO-ILE) are key components of parenteral nutrition and require importation into Japan, and they are easily oxidized after opening. Given the small daily volumes of these lipids dispensed in infants and children with intestinal failure (IF), the purpose of the study was to identify the optimal storage method.Methods: Lipids were prepared in polypropylene syringes in the following manner: air-sealing and photoprotection, air-sealing only, photoprotection only, and uncovered. Samples were stored for 14 days at 4°C or 26°C. The degree of oxidative degradation was evaluated by measuring malondialdehyde (MDA) concentration and pH and comparing them to the values measured immediately after opening.Results: For FO-ILE, the increase in MDA concentration for 14 days was insignificant in air-sealed samples, regardless of photoprotection (+0.45 μM, P = 1.0) or no photoprotection (+0.52 μM, P = 1.0). This trend was more pronounced at 4°C than at 26°C (P < 0.01). The maximum pH decrease was 0.08 at 4°C. MO-ILE exhibited an insignificant increase in MDA concentration for 14 days with air-sealed samples, regardless of photoprotection (+0.36 μM, P = 0.11) or no photoprotection (+0.33 μM, P = 0.76). This trend was more pronounced at 4°C than at 26°C (P < 0.01). The maximum pH decrease was 0.12 at 4°C. For soybean-oil lipid injectable emulsion, the trend was similar with no considerable deterioration.Conclusion: Syringe-dispensed FO-ILE and MO-ILE stored under airtight refrigeration remained undeteriorated for 14 days. Our results are considered clinically valuable when supplying these expensive resources for infants with IF.This is the peer reviewed version of the following article:[ Makoto Setoguchi, Mitsuru Muto, Tomonori Ohata, Ryuichi Fukuoka, Hirohito Ikeda, Hatsumi Aki, Masaomi Haraguchi, Shota Hanjo, Junko Arima, Satoshi IbaraSyringe-dispensed omega-3 lipid injectable emulsions should be stored under airtight refrigeration: A proposal for the efficient supply of unapproved precious lipid resourcesJournal of Parenteral and Enteral Nutrition. 2022;46:1923–1931. ],which has been published in final form at [ https://doi.org/10.1002/jpen.2443 ]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
• 国立国会図書館永続的識別子: info:ndljp/pid/13235626; https://dl.ndl.go.jp/pid/13235626
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2024-01-19T16:23:17+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10232/00032422
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp