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博士論文
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Isolation and evaluation of anti-inflammatory constituents from lichen Dirinaria applanata and Lasia spinosa leaves
- 国立国会図書館永続的識別子
- info:ndljp/pid/13332039
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一般注記:
- type:ThesisNatural products or traditional medicines play essential roles in therapeutic agents as well as a resource for the discovery of new drugs. ...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- NGUYEN QUOC CHAU THANH
- 出版年月日等
- 2020-09-24
- 出版年(W3CDTF)
- 2020-09-24
- 並列タイトル等
- Dirinaria applanate葉およびLasia spinosa葉に含まれる抗炎症物質の単離と評価
- 授与機関名
- 京都工芸繊維大学
- 授与年月日
- 2020-09-24
- 授与年月日(W3CDTF)
- 2020-09-24
- 報告番号
- 甲第972号
- 学位
- 博士(学術)
- 本文の言語コード
- eng
- 件名標目
- 対象利用者
- 一般
- 一般注記
- type:ThesisNatural products or traditional medicines play essential roles in therapeutic agents as well as a resource for the discovery of new drugs. Lichen Dirinaria applanata and Lasia spinosa (L.) Thwaites were used as traditional medicines to treat many diseases for centuries. However, chemical components and their effects on inflammatory response are not yet characterized. Thus, the goal of this dissertation is to explore chemical positions and investigate the anti-inflammatory activities of these extracts in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Chemical investigation of the lichen Dirinaria applanata methanol extract led to isolating two hopane derivatives including 1β-acetoxy-21α,3β-hydroxyhopane-29-oic acid (1), hopane-3β,6β,21α-triol (2) and a depside namely 2-O′-methylnordivaricatic acid (3). Their structures were elucidated by spectroscopic data in combination with published literature. Notably, compound 2 was isolated from this lichen species for the first time. Unfortunately, only compound 1 shows the anti-inflammatory effect by reducing nitric oxide (NO) production in LPS-induced inflammation response. Besides, ethanol extracts of L. spinosa leaves showed antioxidant activity due to the presence of high levels of polyphenolic compounds. Therefore, L. spinosa leaves may exhibit anti-inflammatory properties. In particular, treatment with the leaf extract significantly repressed the production of inflammatory mediators such as nitric oxide and reactive oxygen species and the expression of pro-inflammatory cytokines in the LPS-stimulated RAW264.7 cells. Moreover, pretreatment of L. spinosa leaf extract prevented activation of the nuclear factor-kappa B (NF-κB) pathway by inhibiting nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα) degradation. Furthermore, the mitogen-activated kinase (MAPK) and phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) pathways were suppressed upon treatment with the leaf extract. In addition to suppressing inflammatory factors, the extract also promoted the activated nuclear factor erythroid 2-related factor 2/heme-oxygenase-1 (Nrf2/HO-1) pathway. Taken together, the significant findings of these herbs will be highlighted and discussed throughout this dissertation. Result obtained highlights critical findings in assessing the potential of anti-inflammatory constituents. Thereby, we propose to further develop them as novel pharmacological strategies in order to defeat inflammation diseases.
- 国立国会図書館永続的識別子
- info:ndljp/pid/13332039
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2024-02-02T16:16:38+09:00
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 掲載誌(URI)
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション