Strong association between insufficient plasma exchange and fatal outcomes in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura.

• 資料種別: 博士論文
• タイトル: Strong association between insufficient plasma exchange and fatal outcomes in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura.
• 著者・編者: Kayashima, Michinori; Sakai, Kazuya; Harada, Kazuki; Kanetake, Jun; Kubo, Masayuki; Hamada, Eriko; Hayakawa, Masaki; Hatakeyama, Kinta; Matsumoto, Masanori
• 著者標目: Kayashima, Michinori; Sakai, Kazuya; Harada, Kazuki; Kanetake, Jun; Kubo, Masayuki; Hamada, Eriko; Hayakawa, Masaki; Hatakeyama, Kinta; Matsumoto, Masanori
• 出版事項: Springer Nature
• 出版年月日等: 2021-10; 114 4
• 出版年（W3CDTF）: 2021-10
• 並列タイトル等: 日本人の免疫性血栓性血小板減少性紫斑病患者における不十分な血漿交換は致死的な転帰と強く相関する
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2021-12-21
• 授与年月日（W3CDTF）: 2021-12-21
• 報告番号: 乙第1518号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Autopsy; Fatal outcome; Plasma exchange; Sudden death; Thrombotic thrombocytopenic purpura
• 対象利用者: 一般
• 一般注記: type:Thesis; Plasma exchange (PEX) using fresh frozen plasma has considerably reduced the mortality rate in patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP). However, some patients still do not survive even with treatment, but little information is available regarding which treatment these patients received. This study was conducted to obtain this information in 240 patients who met the current iTTP diagnostic criteria and completed at least 30 days of follow-up except for deceased cases. These patients were divided into three groups: survivors (n = 195), TTP-related deaths (n = 32), and other cause of death (n = 13). In the TTP-related death group, 26 of 32 patients experienced sudden death, mostly following radical hypotension and bradycardia. The median follow-up time after admission was 5.0 days, and the median number of PEX sessions was 2.5. Nine patients underwent autopsy and had cardiac microvascular thrombi in arterioles. Levels of lactate dehydrogenase, total bilirubin, serum creatinine, and D-dimer were significantly higher in the TTP-related death group than in the survivors group. Frequent PEX (> 20 sessions) was not associated with TTP-related death. In the acute phase of iTTP, patients with substantial organ damage caused by microthrombi have a greater mortality risk, even after just a few PEX sessions.; 博士（医学）・乙第1518号・令和3年12月21日; © Japanese Society of Hematology 2021.; The version of record of this article, first published in International journal of hematology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12185-021-03197-5.; 発行元が定める登録猶予期間終了の後、本文を登録予定（2022.10）; identifier:International journal of hematology Vol.114 No.4 p.415-423 (2021 Oct); identifier:09255710; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3963; identifier:International journal of hematology, 114(4): 415-423
• 国立国会図書館永続的識別子: info:ndljp/pid/13342553; https://dl.ndl.go.jp/pid/13342553
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2024-03-01T22:05:19+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3963
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp