並列タイトル等無症候性腎機能障害が結腸癌術後の臨床経過に及ぼす影響
一般注記type:Thesis
Purpose: To evaluate the effect of mild renal dysfunction on the clinical course after colectomy in patients with colon cancer. Methods: The subjects of this retrospective study were 263 patients who underwent surgical resection for colon cancer at our hospital between 2011 and 2015. Renal function was assessed based on preoperative estimated glomerular filtration rate (eGFR) values. Patients were divided into groups based on their eGFR value of 55 ml/min/1.73 m2. The Mann-Whitney U test, chi-square or Fisher exact test, and log-rank test were used in the data analysis. Results: There were 59 patients (22.4%) in the low eGFR group and 204 patients in the normal eGFR group. There were differences between the groups in age, comorbidities, and the levels of hemoglobin, albumin, and serum creatinine. The overall postoperative complication rate, frequency of severe complications, and length of stay were significantly higher in the low eGFR group than in the normal eGFR group. Multivariate analysis revealed that low eGFR was the only independent risk factor for severe complications (Clavien-Dindo classification III/IV). There were no differences in survival between the groups. Conclusion: Preoperative asymptomatic renal dysfunction may be correlated with the development of postoperative complications and a possible significant risk factor for severe complications after colon cancer surgery.
博士（医学）・甲第804号・令和3年12月21日
© 2021. Springer Nature Singapore Pte Ltd.
The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00595-021-02363-w.
発行元が定める登録猶予期間終了の後、本文を登録予定（2023.01）
identifier:Surgery today Vol.52 No.1 p.106-113 (2022 Jan)
identifier:09411291
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3953
identifier:Surgery today, 52(1): 106-113
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