雄性老化促進マウス (SAMP8) の自然発症型変形性膝関節症に対する低強度運動の効果

• 資料種別: 博士論文
• タイトル: 雄性老化促進マウス (SAMP8) の自然発症型変形性膝関節症に対する低強度運動の効果
• 著者・編者: 則松, 貢輔
• 著者標目: 則松, 貢輔
• 出版事項: BMC
• 出版年月日等: 2024-03-13
• 出版年（W3CDTF）: 2024-03-13
• 並列タイトル等: Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8
• 授与機関名: 鹿児島大学
• 授与年月日: 2024-03-13
• 授与年月日（W3CDTF）: 2024-03-13
• 報告番号: 甲保研第39号
• 学位: 博士(保健学); Doctor of Philosophy in Health Science
• 本文の言語コード: eng
• 件名標目: Aging; Osteoarthritis; Exercise; Rehabilitation; Mouse model; Synovial inflammation; M1 macrophage
• 対象利用者: 一般
• 一般注記: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: Osteoarthritis (OA) is a degenerative joint disease associated with aging, which often leads to joint stiffness and disability. Exercise is one of the most important non-pharmacological treatments and is prescribed as an indispensable treatment for OA. However, whether physical exercise is beneficial for preventing the progression of OA symptoms with age is poorly understood. We investigated the effects of exercise on spontaneously developed knee OA using male senescence-accelerated mouse prone 8 (SAMP8).Methods: To examine age-related changes in the knee joints of SAMP8, knee articular cartilage changes, synovitis, knee joint flexion and extension angles, swelling, walking ability, and quadriceps muscle atrophy were analyzed at 3, 5, 7, and 9 months. SAMP8 were required to run at a speed of 10 m/min for 15 min/day from 7 to 9 months of age. The knee joint pathologies and symptoms of exercising and non-exercising mice were compared by histological, immunohistochemical, and morphometrical analyses.Results: The mice presented with various histological changes, including cartilage destruction, osteocyte formation, synovitis, declined joint angles, and swelling. Notably, medial and posterior cartilage destruction was more severe than that of the lateral and anterior cartilage. Knee joint angles were significantly correlated with the histological scores (modified Mankin and OARSI, osteophyte formation and synovial lining cell layer). Exercise did not attenuate cartilage degeneration in the medial and posterior tibial plateau, although the articular cartilage of the anterior and lateral tibial plateau and its histological scores was remained and significantly improved, respectively, by exercise. Exercise suppressed the age-related decline of collagen type II-positive areas in the remaining articular cartilage and improved the OA symptoms. Exercise reduced the expression of monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor (TNF)-α positive macrophages in the synovium.Conclusion: This study revealed that SAMP8 developed spontaneous knee OA with age, which resembled the disease symptoms in humans. Low-intensity exercise temporarily alleviated degeneration of the remaining cartilage, synovitis, and age-related decreases in knee flexion angle, stride length, and muscle atrophy in SAMP8. However, exercise during OA progression with age may cause mechanical stress that could be both beneficial and detrimental to joint health.Kosuke Norimatsu, Kazuki Nakanishi, Toshiro Ijuin, Shotaro Otsuka, Seiya Takada, Akira Tani, Ryoma Matsuzaki, Teruki Matsuoka & Harutoshi SakakimaEffects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8Norimatsu et al. Arthritis Research & Therapy (2023) 25:168https://doi.org/10.1186/s13075-023-03162-z
• 国立国会図書館永続的識別子: info:ndljp/pid/13521772; https://dl.ndl.go.jp/pid/13521772
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2024-04-05T22:42:23+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10232/0002000173
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2024-06-08 再収集

2024-06-08 再収集