Relationship between Stress Levels and Endolymphatic Space Volume in Meniere’s Disease 6

• 資料種別: 博士論文
• タイトル: Relationship between Stress Levels and Endolymphatic Space Volume in Meniere’s Disease
• 巻次・部編番号: 50 6
• 著者・編者: Fujita, Hiroto; Ueda, Keita; Kageyama, Hajime; Shiozaki, Tomoyuki; Inui, Hiroshi; Kitahara, Tadashi
• 著者標目: Fujita, Hiroto; Ueda, Keita; Kageyama, Hajime; Shiozaki, Tomoyuki; Inui, Hiroshi; Kitahara, Tadashi
• 出版事項: Elsevier B.V.
• 出版年月日等: 2023-04; 50 6
• 出版年（W3CDTF）: 2023-04
• 並列タイトル等: メニエール病におけるストレスレベルと内リンパ腔容積の関係
• タイトル（掲載誌）: Auris Nasus Larynx
• 掲載ページ: 866-873
• ISSN（掲載誌）: 03858146
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2024-03-14
• 授与年月日（W3CDTF）: 2024-03-14
• 報告番号: 甲第898号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Meniere's disease; endolymphatic hydrops volume; depression; stress; vasopressin; 3D inner ear MRI
• 対象利用者: 一般
• 一般注記: type:Thesis; Objectives: Since the first report by Hallpike and Yamakawa in 1938, many more patients with Meniere's disease (MD) with endolymphatic hydrops (EHs) have been described. Mental/physical stress and a subsequent increase in the release of the anti-diuretic hormone (ADH) supposedly triggers MD. In the present study, to assess the relationship between stress and EHs, we conducted a series of stress-related questionnaires as well as a 3D endolymphatic space (ELS) analysis in patients with unilateral MD. Methods: We enrolled 76 patients with unilateral MD (uMD) as the active group and 75 patients with unilateral benign paroxysmal positional vertigo (uBPPV) as the control group; both underwent examinations between June 2014 and November 2019. All patients underwent 3-T magnetic resonance imaging (MR1) 4 h after intravenous gadolinium injection. We used the total fluid space (TFS), ELS, and ELS rate (ELS/TFSxl00), which is the percentage of the volume of the ELS relative to that of the TFS, for a precise evaluation of the ELS and EHs in MD. Stress was evaluated using the SelfRating Depression Scale (SDS), the psychological Stress Response Scale (SRS), and the modified Dizziness Handicap Inventory (mDHI). Stress scores and blood ADH levels were compared across patient groups. Results: In patients with uMD, ELS rates significantly correlated with SRS scores on both the affected and the healthy side and with mDHI scores on the affected side, while the SDS and ADH showed no significant correlation with the ELS rates. Correlations were much stronger in the group with severe SDS and one with low ADH levels. Conclusions: The present results indicate that stress may be involved in EHs development in uMD, not only in the ipsilateral but also the contralateral ear. They also suggest that patients with neuropsychiatric tendencies may develop EHs and MD in response to a stressful lifestyle.; 権利情報：©2023 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.; identifier:Auris Nasus Larynx. 2023 Dec, vol.50, no.6, p.866-873; identifier:0385-8146; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4349; identifier:Auris Nasus Larynx, 50(6): 866-873
• 国立国会図書館永続的識別子: info:ndljp/pid/13700887; https://dl.ndl.go.jp/pid/13700887
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2024-06-07T22:11:46+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: https://doi.org/10.1016/j.anl.2023.03.006
• 掲載誌（URI）: http://hdl.handle.net/10564/4349
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp