Anticoagulant effects of protein C, protein S, and antithrombin levels on the protein C pathway in young children 2

• 資料種別: 博士論文
• タイトル: Anticoagulant effects of protein C, protein S, and antithrombin levels on the protein C pathway in young children
• 巻次・部編番号: 119 2
• 著者・編者: Nakagawa, Takashi; Ogiwara, Kenichi; Tonegawa, Hitoshi; Takahashi, Yukihiro; Nishikubo, Toshiya; Nogami, Keiji
• 著者標目: Nakagawa, Takashi; Ogiwara, Kenichi; Tonegawa, Hitoshi; Takahashi, Yukihiro; Nishikubo, Toshiya; Nogami, Keiji
• 出版事項: Springer
• 出版年月日等: 2024-02; 119 2
• 出版年（W3CDTF）: 2024-02
• 並列タイトル等: 新生児、乳幼児におけるPC経路でのプロテインC、プロテインS、アンチトロンビンの抗凝固作用
• タイトル（掲載誌）: The Journal of Dermatology
• 掲載ページ: 196-204
• ISSN（掲載誌）: 09255710
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2024-06-26
• 授与年月日（W3CDTF）: 2024-06-26
• 報告番号: 乙第1532号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: developmental hemostasis; protein C; protein S; antithrombin; thrombin generation
• 対象利用者: 一般
• 一般注記: type:Thesis; The protein C (PC) pathway involves physiological anticoagulant factors (PC, protein S [PS], and factor V) and performs major anticoagulant functions in adults. Variations in the overall PC pathway function due to dynamic changes in PC and PS in early childhood are poorly understood. We aimed to evaluate the contributions of PC pathway function during early childhood by administering protac (a PC activator) and measuring changes in plasma thrombin generation (TG). The correlations between anticoagulant factors and percentage of protac-induced coagulation inhibition (PiCi%) were assessed. Before protac addition, TG in newborns (n=35), infants (n=42), early children (n=35), and adults (n=20) were 525±74, 720±96, 785±53, and 802±64 mOD/min, and the PiCi% were 42.1±9.9, 69.8±11.0, 82.9±4.4, and 86.9±3.4%, respectively. The distribution of PiCi% on the two axes of TG (with or without protac) continuously changed with age and differed from that of warfarin-treated plasma or adult PC- or PS-deficient plasma. PiCi% increased dynamically during infancy and correlated with PS levels in newborns and PC levels in young children. Increment of PC or fresh frozen plasma equivalent to approximately 25% PC in PC-deficient plasma improved PiCi%. This automatic measurement requiring a small sample volume is useful for the analysis of developmental hemostasis.; 権利情報：© Japanese Society of Hematology 2024. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10157-023-02433-y; identifier:The Journal of Dermatology. 2024 Feb, vol.119, no.2, p.196-204; identifier:0925-5710; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4391; identifier:The Journal of Dermatology, 119(2): 196-204
• 国立国会図書館永続的識別子: info:ndljp/pid/14053916; https://dl.ndl.go.jp/pid/14053916
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2025-02-07T22:15:48+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: https://doi.org/10.1007/s12185-023-03699-4
• 掲載誌（URI）: http://hdl.handle.net/10564/4391
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp