Role of Epiregulin on Lipopolysaccharide-Induced Hepatocarcinogenesis as a Mediator via EGFR Signaling in the Cancer Microenvironment 8

• 資料種別: 博士論文
• タイトル: Role of Epiregulin on Lipopolysaccharide-Induced Hepatocarcinogenesis as a Mediator via EGFR Signaling in the Cancer Microenvironment
• 巻次・部編番号: 25 8
• 著者・編者: Kubo, Takahiro; Nishimura, Norihisa; Kaji, Kosuke; Tomooka, Fumimasa; Shibamoto, Akihiko; Iwai, Satoshi; Suzuki, Junya; Kawaratani, Hideto; Namisaki, Tadashi; Akahane, Takemi; Yoshiji, Hitoshi
• 著者標目: Kubo, Takahiro; Nishimura, Norihisa; Kaji, Kosuke; Tomooka, Fumimasa; Shibamoto, Akihiko; Iwai, Satoshi; Suzuki, Junya; Kawaratani, Hideto; Namisaki, Tadashi; Akahane, Takemi; Yoshiji, Hitoshi
• 出版事項: MDPI
• 出版年月日等: 2024-04; 25 8
• 出版年（W3CDTF）: 2024-04
• 並列タイトル等: がん微小環境におけるEGFRシグナルを介したメディエーターとしての肝発がんに対するエピレグリンの役割
• タイトル（掲載誌）: International Journal of Molecular Sciences
• 掲載ページ: 4405-
• ISSN（掲載誌）: 16616596
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2024-12-26
• 授与年月日（W3CDTF）: 2024-12-26
• 報告番号: 甲第938号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: epiregulin; interleukin-8; lipopolysaccharides; tumor angiogenesis; tumor microenvironment
• 対象利用者: 一般
• 一般注記: type:Thesis; Lipopolysaccharides (LPSs) have been reported to be important factors in promoting the progression of hepatocellular carcinoma (HCC), but the corresponding molecular mechanisms remain to be elucidated. We hypothesize that epiregulin (EREG), an epidermal growth factor (EGF) family member derived from hepatic stellate cells (HSCs) and activated by LPS stimulation, is a crucial mediator of HCC progression with epidermal growth factor receptor (EGFR) expression in the tumor microenvironment. We used a mouse xenograft model of Huh7 cells mixed with half the number of LX-2 cells, with/without intraperitoneal LPS injection, to elucidate the role of EREG in LPS-induced HCC. In the mouse model, LPS administration significantly enlarged the size of xenografted tumors and elevated the expression of EREG in tumor tissues compared with those in negative controls. Moreover, CD34 immunostaining and the gene expressions of angiogenic markers by a reverse transcription polymerase chain reaction revealed higher vascularization, with increased interleukin-8 (IL-8) expression in the tumors of the mice group treated with LPS compared to those without LPS. Our data collectively suggested that EREG plays an important role in the cancer microenvironment under the influence of LPS to increase not only the tumor cell growth and migration/invasion of EGFR-positive HCC cells but also tumor neovascularization via IL-8 signaling.; 権利情報：© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).; identifier:International Journal of Molecular Sciences. 2024 Apr, vol.25, no.8, article no.4405; identifier:1661-6596; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4414; identifier:International Journal of Molecular Sciences, 25(8): 4405
• 国立国会図書館永続的識別子: info:ndljp/pid/14053938; https://dl.ndl.go.jp/pid/14053938
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2025-02-07T22:15:49+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: https://doi.org/10.3390/ijms25084405
• 掲載誌（URI）: http://hdl.handle.net/10564/4414
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp