並列タイトル等近赤外線スペクトロスコピィで測定された成人強迫性障害における前頭前野の活動性の低下
タイトル（掲載誌）Progress in neuro-psychopharmacology & biological psychiatry
一般注記type:Thesis
Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Here we used NIRS to investigate neurobiological function in 12 patients with OCD and 12 age- and sex-matched, healthy control subjects. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 sec, during performance of a Stroop color-word task, using 24-channel NIRS. Oxy-Hb changes in the prefrontal cortex of the OCD group were significantly smaller than those in the control group, especially in the left lateral prefrontal cortex. These results suggest that patients with OCD have reduced prefrontal hemodynamic responses as measured by NIRS.
博士（医学）・甲第599号・平成25年5月29日
Copyright © 2012 Elsevier Inc. All rights reserved.
identifier:Progress in neuro-psychopharmacology & biological psychiatry Vol.43 p.7-13 (2013 Jun)
identifier:02785846
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2587
identifier:Progress in neuro-psychopharmacology & biological psychiatry, 43: 7-13
DOIinfo:doi/10.1016/j.pnpbp.2012.11.013
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