並列タイトル等1250nm帯モード同期クロム・フォルステライトレーザーを光源とした第2高調波発生光顕微鏡によるヒト顔皮膚の老化性真皮コラーゲン構造変化のその場観察
タイトル(掲載誌)Journal of biomedical optics
一般注記type:Thesis
In vivo visualization of human skin aging is demonstrated using a Cr:Forsterite (Cr:F) laser-based, collagen-sensitive second harmonic generation (SHG) microscope. The deep penetration into human skin, as well as the specific sensitivity to collagen molecules, achieved by this microscope enables us to clearly visualize age-related structural changes of collagen fiber in the reticular dermis. Here we investigated intrinsic aging and/or photoaging in the male facial skin. Young subjects show dense distributions of thin collagen fibers, whereas elderly subjects show coarse distributions of thick collagen fibers. Furthermore, a comparison of SHG images between young and elderly subjects with and without a recent life history of excessive sun exposure show that a combination of photoaging with intrinsic aging significantly accelerates skin aging. We also perform image analysis based on two-dimensional Fourier transformation of the SHG images and extracted an aging parameter for human skin. The in vivo collagen-sensitive SHG microscope will be a powerful tool in fields such as cosmeceutical sciences and anti-aging dermatology.
博士(医学)・乙第1311号・平成25年5月29日
identifier:Journal of biomedical optics Vol.18 No.3 p.31108(1-10)
identifier:10833668
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2589
identifier:Journal of biomedical optics, 18(3): 31108-1-31108-10
DOIinfo:doi/10.1117/1.JBO.18.3.031108
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