Phosphorylation status of Fas-associated death domain protein is associated with biochemical recurrence after radical prostatectomy 3

• 資料種別: 博士論文
• ISSN: 0090-4295
• タイトル: Phosphorylation status of Fas-associated death domain protein is associated with biochemical recurrence after radical prostatectomy
• 巻次・部編番号: 81 3
• 著者・編者: Ikeda, Tomohiro; Tanaka, Nobumichi; Shimada, Keiji; Matsumura, Yoshiaki; Miyake, Makito; Anai, Satoshi; Tomioka, Atsushi; Okajima, Eijiro; Hirayama, Akihide; Fujimoto, Kiyohide; Konishi, Noboru; Hirao, Yoshihiko
• 著者標目: Ikeda, Tomohiro; Tanaka, Nobumichi; Shimada, Keiji; Matsumura, Yoshiaki; Miyake, Makito; Anai, Satoshi; Tomioka, Atsushi; Okajima, Eijiro; Hirayama, Akihide; Fujimoto, Kiyohide; Konishi, Noboru; Hirao, Yoshihiko
• 出版事項: Elsevier Science
• 出版年月日等: 2013-03; 81 3
• 出版年（W3CDTF）: 2013-03
• 並列タイトル等: FADDのリン酸化の状態と根治的前立腺全摘除術後の生化学的再発は関連する
• タイトル（掲載誌）: Urology
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2013-05-29
• 授与年月日（W3CDTF）: 2013-05-29
• 報告番号: 乙第1313号
• 学位: 博士（医学）
• 博論授与番号: 乙第1313号
• 本文の言語コード: eng
• 件名標目: Prostate cancer; radical prostatectomy; prognostic factor; biochemical recurrence; p-FADD
• 対象利用者: 一般
• 一般注記: type:Thesis; OBJECTIVE: To assess whether the phosphorylated Fas-associated death domain protein (FADD) at 194 serine (p-FADD) is valuable as a marker of biochemical recurrence in hormone-naive patients who had undergone radical prostatectomy.MATERIALS AND METHODS: We used radical prostatectomy specimens from 106 patients. None of the patients had received neoadjuvant or adjuvant therapy. The percentage of positive p-FADD cells (nuclear staining) was immunohistochemically evaluated. The correlation between FADD phosphorylation and the clinicopathologic parameters was assessed. The correlation between the biochemical recurrence-free rate and the p-FADD expression level was analyzed using the Kaplan-Meier method.RESULTS: Overall, 39 patients developed biochemical recurrence. We investigated the expression of p-FADD in 106 patients with prostate cancer using immunohistochemistry. We compared our findings with the clinicopathologic parameters, including the follow-up data. Patients with a greater positive p-FADD rate had a significantly lower biochemical recurrence rate than those with a lower positive p-FADD rate (P < .001). A significant inverse correlation was found between the positive p-FADD rate and the Gleason score.CONCLUSION: A low expression of p-FADD could be a predictor of biochemical recurrence in hormone-naive patients who have undergone radical prostatectomy.; 博士（医学）・乙第1313号・平成25年5月29日; identifier:Urology Vol.81 No.3 p.607-610; identifier:00904295; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2591; identifier:Urology, 81(3): 607-610
• DOI: info:doi/10.1016/j.urology.2012.11.032; https://doi.org/info:doi/10.1016/j.urology.2012.11.032
• 国立国会図書館永続的識別子: info:ndljp/pid/8948168; https://dl.ndl.go.jp/pid/8948168
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 公開開始日（W3CDTF）: 2015-03-03
• 受理日（W3CDTF）: 2015-02-03T05:25:05+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/2591
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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