タイトル(掲載誌)Child psychiatry and human development
一般注記type:Thesis
Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. Functional neuroimaging studies of patients with obsessive–compulsive disorder (OCD) have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of the disorder. Twelve treatment-naïve children with OCD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s during the Stroop color-word task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the OCD group were significantly smaller than those in the control group in the prefrontal cortex, especially in the frontopolar cortex. The present study suggests that children with OCD have reduced prefrontal hemodynamic response as measured by NIRS.
博士(医学)・乙第1315号・平成25年7月22日
identifier:Child psychiatry and human development Vol.44 No.2 p.265-277
identifier:0009398X
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2637
identifier:Child psychiatry and human development, 44(2): 265-277
DOIinfo:doi/10.1007/s10578-012-0323-0
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受理日(W3CDTF)2015-02-03T05:25:05+09:00
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