並列タイトル等Serum Intestinal Fatty Acid Binding Protein in Patients with Small Bowel Obstruction
腸閉塞患者における血中ヒト腸型脂肪酸結合蛋白濃度推移に関する検討
一般注記Purpose: The aims of this pilot study were to reveal the biological characteristics of serum I-FABP and explore its clinical utility as a biomarker in patients with small bowel obstruction (SBO). Methods: Serum I-FABP levels were measured in 37 consecutive patients with SBO between 2007 and 2008. Serum I-FABP levels were compared between ischemia (n = 10) and non-ischemia (n = 27) groups. Serum I-FABP levels were longitudinally analyzed in 21 patients who showed high (>2.0 ng/ml) serum I-FABP levels. The relationship between serum I-FABP level and length of damaged bowel was also analyzed. Results: Median serum I-FABP levels were 9.2 ng/ml in the ischemia group and 1.9 ng/ml in the non-ischemia group (p < 0.0001). The elevated I-FABP levels rapidly decreased after therapeutic intervention and normalized on the third day in all patients. Linear regression analysis revealed a positive correlation between I-FABP levels and lengths of surgically excised bowels (y = 2.527x － 7.660, r = 0.604, p = 0.0018). By setting the cutoff level at 7.2 ng/ml, the diagnostic ability of serum I-FABP was 70.0% in terms of sensitivity, 92.6% in terms of specificity, and 86.5% in terms of accuracy. Conclusion: Serum I-FABP sensitively reflects bowel damage in SBO patients and seems to be a potential biomarker for detecting small-bowel ischemia.
学位の種類: 博士（医学）. 報告番号: 甲第3805号. 学位記番号: 新大院博（医）甲第557号. 学位授与年月日: 平成25年9月20日
Surgical Science. 2013, 4(6), 302-307
新大院博（医）甲第557号
元資料の権利情報 : Copyright © 2013 Kaoru Sakamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOIinfo:doi/10.4236/ss.2013.46059
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2015-02-03T05:25:05+09:00
連携機関・データベース国立国会図書館 : 国立国会図書館デジタルコレクション