Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren's syndrome

• 資料種別: 博士論文
• ISSN: 0009-9104
• タイトル: Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren's syndrome
• 巻次・部編番号: 174 1
• 著者・編者: Yoshimoto, Kiyomi; Fujimoto, Takashi; Itaya-Hironaka, Asako; Miyaoka, Tomoko; Sakuramoto-Tsuchida, Sumiyo; Yamauchi, Akiyo; Takeda, Maiko; Kasai, Takahiko; Nakagawara, Kan-ichi; Nonomura, Akitaka; Takasawa, Shin
• 著者標目: Yoshimoto, Kiyomi; Fujimoto, Takashi; Itaya-Hironaka, Asako; Miyaoka, Tomoko; Sakuramoto-Tsuchida, Sumiyo; Yamauchi, Akiyo; Takeda, Maiko; Kasai, Takahiko; Nakagawara, Kan-ichi; Nonomura, Akitaka; Takasawa, Shin
• 出版事項: Blackwell Scientific Pub.
• 出版年月日等: 2013-10; 174 1
• 出版年（W3CDTF）: 2013-10
• 並列タイトル等: 原発性シェーグレン症候群患者における再生因子REG(regenerating gene)に対する自己免疫の関与
• タイトル（掲載誌）: Clinical and experimental immunology
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2013-11-27
• 授与年月日（W3CDTF）: 2013-11-27
• 報告番号: 乙第1319号
• 学位: 博士（医学）
• 博論授与番号: 乙第1319号
• 本文の言語コード: eng
• 件名標目: REG family genes; REG Iα protein; anti-REG Iα autoantibodies; Sjögren’s syndrome; ductal epithelial cells
• 対象利用者: 一般
• 一般注記: type:Thesis; The regenerating gene (Reg) was isolated originally as a gene specifically over-expressed in regenerating pancreatic islets and constitute a growth factor family. Reg gene product (Reg) is important in the pathophysiology of various human inflammatory diseases. Recently, the possible involvement of human REG in the regeneration of salivary ductal epithelial cells of patients with primary Sjögren's syndrome (SS) was reported. However, the expression of the REG family genes in minor salivary glands (MSG) and the occurrence of anti-REG Iα autoantibodies in SS patients were obscured. In this study, we examined the expression of REG family genes in the MSG of SS and screened anti-REG Iα autoantibodies in SS. The mRNA levels of REG family genes in MSG were quantified using real-time reverse transcription-polymerase chain reaction (RT-PCR) and REG Iα expression in the MSG was analysed by immunohistochemistry. The mRNA level of REG Iα in the MSG of SS patients was significantly higher than that of control. REG Iα protein was expressed highly in SS ductal epithelial cells. Anti-REG Iα autoantibodies in the sera were found in 11% of SS. All the MSG in the anti-REG Iα autoantibody-positive group showed REG Iα expression, whereas only 40% showed REG Iα expression in the anti-REG Iα autoantibody-negative group. The anti-REG Iα autoantibody-positive group showed significantly lower saliva secretion and a higher ratio of grade 4 (by Rubin-Holt) in sialography. These data suggest strongly that autoimmunity to REG Iα might play a role in the degeneration of MSG ductal epithelial cells in primary SS.; 博士（医学）・乙第1319号・平成25年11月27日; The definitive version is available at " http://dx.doi.org/10.1111/cei.12142 "; identifier:Clinical and experimental immunology Vol.174 No.1 p.1-9; identifier:00099104; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2674; identifier:Clinical and experimental immunology, 174(1): 1-9
• DOI: info:doi/10.1111/cei.12142; https://doi.org/info:doi/10.1111/cei.12142
• 国立国会図書館永続的識別子: info:ndljp/pid/8949102; https://dl.ndl.go.jp/pid/8949102
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 公開開始日（W3CDTF）: 2015-03-03
• 受理日（W3CDTF）: 2015-02-03T05:25:05+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/2674
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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