タイトル（掲載誌）Journal of biomedical science and engineering Vol. No. p.
一般注記type:Thesis
The aim of the study is to clarify the vitreous body structure and liquefaction phenomena. It was found that when melting a frozen rabbit vitreous body, the gel-sol transition phenomenon occurs and the gel structure is broken. This is almost like the liquefaction of the vitreous body in vivo. We try to clarify the liquefaction phenomenon by using this animal model. The native vitreous body has three dimensional meshwork structures. After liquefaction, it is changed into two parts, namely fiber aggregates and soluble amorphous aggregates. The surface of native vitreous body meshwork is mucopolysacharide, but that of fiber aggregates after liquefaction is changed into connective tissue, which means the conformational change of vitreous body in liquefaction. The soluble proteins after liquefaction were analyzed and identified as crystallin family. It is suggested that the liquefaction is induced by detachment of non-collagenous protein beads containing crystallins, resulting in the collapse of the three dimensional structure to release watery liquid trapped within. And the new gel-sol transition model of vitreous bod is proposed.
博士（医学）・乙1330号・平成26年3月17日
identifier:Journal of biomedical science and engineering Vol.6 No.7 p.739-745
identifier:19376871
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2715
identifier:Journal of biomedical science and engineering Vol. No. p., 6(7): 739-745
DOIinfo:doi/10.4236/jbise.2013.67091
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2015-02-03T05:25:05+09:00
連携機関・データベース国立国会図書館 : 国立国会図書館デジタルコレクション