Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma.

• 資料種別: 博士論文
• ISSN: 0007-0920
• タイトル: Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma.
• 巻次・部編番号: 110 4
• 著者・編者: Tanaka, Tetsuya; Sho, Masayuki; Takayama, Tomoyoshi; Wakatsuki, Kohei; Matsumoto, Sohei; Migita, Kazuhiro; Ito, Masahiro; Hamada, Kaoru; Nakajima, Yoshiyuki
• 著者標目: Tanaka, Tetsuya; Sho, Masayuki; Takayama, Tomoyoshi; Wakatsuki, Kohei; Matsumoto, Sohei; Migita, Kazuhiro; Ito, Masahiro; Hamada, Kaoru; Nakajima, Yoshiyuki
• 出版事項: Nature Publishing Group
• 出版年月日等: 2014-02; 110 4
• 出版年（W3CDTF）: 2014-02
• 並列タイトル等: 食道扁平上皮癌におきてエンドセリンB受容体の高発現は腫瘍の血管新生と予後に関与する
• タイトル（掲載誌）: British journal of cancer
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2014-05-28
• 授与年月日（W3CDTF）: 2014-05-28
• 報告番号: 乙第1336号
• 学位: 博士（医学）
• 博論授与番号: 乙第1336号
• 本文の言語コード: eng
• 件名標目: endothelin B receptor; oesophageal cancer; angiogenesis
• 対象利用者: 一般
• 一般注記: type:Thesis; BACKGROUND:The endothelin axis has been shown to have a pivotal role in several human malignancies. The aim of this study was to clarify the clinical importance of endothelin receptor type B (ETBR) in human oesophageal squamous cell carcinoma (OSCC).METHODS:We evaluated ETBR expression in 107 patients with OSCC by immunohistochemistry. Microvessel density (MVD) and lymphatic vessel density were assessed by CD31 and D2-40 immunostaining, respectively. Furthermore, CD4, CD8, and CD45RO+ tumour-infiltrating lymphocytes (TILs) were immunohistochemically analysed.RESULTS:Sixty-one (57%) cases showed high expression of ETBR. Endothelin receptor type B expression was correlated with several clinicopathological factors including tumour differentiation, tumour depth, and lymph node metastasis. The overall and disease-specific survival rates were significantly lower in patients with high ETBR expression than patients with low expression. Furthermore, multivariate analysis revealed that ETBR status was an independent prognostic factor for patient survival. Mechanistic analysis indicated that MVD was significantly higher in tumour tissues with high ETBR expression compared with those with low expression, suggesting that angiogenesis may be a key mechanism in tumour progression and metastasis of OSCC mediated by ETBR expression. By contrast, there were no significant correlations between TILs and ETBR expression.CONCLUSION:Endothelin receptor type B has a pivotal role in oesophageal cancer and may be therapeutic target for this intractable malignancy.; 博士（医学）・乙第1336号・平成26年5月28日; identifier:British journal of cancer Vol.110 No.4 p.1027-1033; identifier:00070920; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2720; identifier:British journal of cancer, 110(4): 1027-1033
• 国立国会図書館永続的識別子: info:ndljp/pid/8950891; https://dl.ndl.go.jp/pid/8950891
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 公開開始日（W3CDTF）: 2015-03-03
• 受理日（W3CDTF）: 2015-02-03T05:25:05+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/2720
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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