並列タイトル等自己分解性を有する生体接着剤 LYDEX の関節軟骨に対する接着性の検討
授与機関名広島大学(Hiroshima University)
一般注記Aim: Until recently, only fibrin glue has been available for clinical usage to repair articular cartilage, although its adhesiveness is not strong enough for use with articular cartilage, and it is derived from human blood and thus carries the risk of contamination. Recently, LYDEX, a new biodegradable hydrogel glue, has come onto the market. The purpose of this study was to evaluate the adhesive strength and cytotoxicity of LYDEX when used on articular cartilage.
Materials and Methods: The differing adhesive strengths of collagen membrane and articular cartilage with LYDEX versus with fibrin glue were measured using a tensile tester. In addition, the cytotoxity of LYDEX in vitro was evaluated. The cytotoxity of LYDEX for the articular cartilage of rats was evaluated histopathologically.
Results: The adhesive strength of LYDEX was significantly stronger than that of fibrin glue, giving values about 3.8 times higher. LYDEX has no discernible effect on normal articular cartilage.
Conclusions: Our study is the first to assess the usefulness and safety of LYDEX for use on articular cartilage.
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受理日（W3CDTF）2015-02-03T05:25:05+09:00
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