Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis

• 資料種別: 博士論文
• タイトル: Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis
• 著者・編者: KITAJIMA, TAKAHITO
• 著者標目: KITAJIMA, TAKAHITO
• 出版事項: 三重大学
• 出版年月日等: 2015-01-01
• 出版年（W3CDTF）: 2015-01-01
• 授与機関名: 三重大学
• 授与年月日: 2015-03-25
• 授与年月日（W3CDTF）: 2015-03-25
• 報告番号: 甲医学第1701号
• 学位: 博士(医学)
• 博論授与番号: 甲医学第1701号
• 本文の言語コード: eng
• 著者別名: キタジマ, タカヒト; 北嶋, 貴仁
• 件名標目: Colorectal cancer; vasohibin-1; angiogenesis
• 対象利用者: 一般
• 一般注記: application/pdf; Background: Vasohibin-1 (VASHI) is related to angiogenesis and poor prognosis in several types of cancers. However, the biological function and clinical significance of VASHI in colorectal cancer (CRC) are not fully known. Materials and Methods: The associations between VASHI expression and clinicopathological features were investigated by immunohistochemistry in 429 CRC tissues. To evaluate the function of VASHI in vitro, small-interfering VASHT targeting RNA was transfected into human CRC cell lines. Results: We found that VASHI was highly expressed in the cytoplasm of CRC tissues. High VASHI expression in the cytoplasm was significantly associated with tumor progression, such as larger tumor size, advanced T-stage, lymph node metastasis, distant metastasis and poor prognosis. Moreover, a significant positive correlation was detected between VASH1 expression and microvessel density. VASHI siRNA inhibited CRC cell proliferation, migration, and invasion, and promoted anoikis. Conclusion: Overexpression of VASHI in CRC cells increased malignant potential and promoted metastasis.; 本文 / Department of Gastrointestinal and Pediatric Surgery，Mie University Graduate School of Medicine; 10p; http://ar.iiarjournals.org/content/34/10/5321.abstract
• 国立国会図書館永続的識別子: info:ndljp/pid/9529837; https://dl.ndl.go.jp/pid/9529837
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2015-11-01T14:53:18+09:00
• 作成日（W3CDTF）: 2017-02-18
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: http://ar.iiarjournals.org/content/34/10/5321.abstract
• 掲載誌（URI）: http://hdl.handle.net/10076/14722; https://mie-u.repo.nii.ac.jp/records/7830
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集