The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit.

• 資料種別: 博士論文
• ISSN: 0378-3782
• タイトル: The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit.
• 巻次・部編番号: 91 8
• 著者・編者: Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin; Takahashi, Yukihiro
• 著者標目: Enami, Nobuko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin; Takahashi, Yukihiro
• 出版事項: Elsevier
• 出版年月日等: 2015-08; 91 8
• 出版年（W3CDTF）: 2015-08
• 並列タイトル等: CD38 genotype (rs1800561 (4693C > T): R140W)は新生児集中治療室への入院のリスク増加に関連する
• タイトル（掲載誌）: Early human development
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-11-27
• 授与年月日（W3CDTF）: 2015-11-27
• 報告番号: 甲第639号
• 学位: 博士（医学）
• 博論授与番号: 甲第639号
• 本文の言語コード: eng
• 件名標目: CD38; Preterm birth; OXTR; SNP
• 対象利用者: 一般
• 一般注記: type:Thesis; BACKGROUNDS:Preterm birth (PTB)/admission to the neonatal intensive care unit (NICU) is a complex disorder associated with significant neonatal mortality and morbidity and long-term adverse health consequences. Multiple lines of evidence suggest that genetic factors play an important role in its etiology.AIM:Given the role of CD38 in term delivery through oxytocin (OXT) release, we hypothesized that OXT signaling may play a role in the etiology of PTB/admission to the NICU. This study was designed to identify genetic variation in the CD38-oxytocin pathway associated with PTB/admission to the NICU.METHODS:To identify common genetic variants predisposing individuals to PTB/admission to the NICU, we genotyped two single nucleotide polymorphisms (SNPs) in the CD38-oxytocin pathway in 63 case mothers, 55 control mothers, and 188 female volunteers in Nara Medical University Hospital, Japan.RESULTS:Maternal genetic effect analysis of the SNP genotype data revealed a significant association between an SNP in CD38 (rs1800561 (4693C>T): R140W), which was reported to be correlated with diabetes and autism, and the risk of NICU admission. On the other hand, an SNP in the oxytocin receptor (OXTR) (rs2254298) showed no correlation with the risk of NICU admission.CONCLUSION:Our study points to an association between maternal common polymorphisms in the CD38 (rs1800561) gene in Japanese women and susceptibility to PTB/admission to the NICU. Future studies with larger sample sizes are needed to confirm the findings of this study.; 博士（医学）・甲第639号・平成27年11月27日; Copyright © 2015 Elsevier B.V. All rights reserved.; identifier:Early human development Vol.91, No.8 p.467-470(2015 Aug); identifier:03783782; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3100; identifier:Early human development, 91(8): 467-470
• DOI: info:doi/10.1016/j.earlhumdev.2015.05.002; https://doi.org/info:doi/10.1016/j.earlhumdev.2015.05.002
• 国立国会図書館永続的識別子: info:ndljp/pid/9577779; https://dl.ndl.go.jp/pid/9577779
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-01-05T14:58:43+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3100
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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