並列タイトル等良性の子宮内膜症性嚢胞と悪性転化を鑑別するのに腫瘍内容液中の鉄関連物質が有用なマーカーとなる
一般注記type:Thesis
OBJECTIVE: The purpose of this study was to investigate cyst fluid levels of total iron, heme iron and free iron in benign endometriotic cysts and endometriosis-associated ovarian cancer (EAOC) and to demonstrate the significance of these biomarkers in differential diagnosis between EAOC and endometriotic cysts. METHODS: Cyst fluid samples were obtained from eleven patients with EAOC and thirty-six women with benign endometriotic cysts at the time of surgery. RESULTS: The median (± SD) total iron levels for endometriotic cysts and EAOC cysts were 244.4 ± 204.9 mg/L and 14.2 ± 36.6 mg/L, respectively. EAOC patients had much lower levels of iron-related compounds compared with endometriotic cyst samples (p< 0.001). When the total iron results were analyzed using the receiver operating characteristics (ROC) curve method, the optimum diagnostic cut-off point was 64.8 mg/L, sensitivity was 90.9%, specificity was 100%, positive predictive value (PPV) was 100%, and negative predictive value (NPV) was 97.3%. Patient demographic characteristics such as tumor size, age at operation, parity and menopause were not correlated with cyst fluid iron levels. CONCLUSIONS: We conclude for the first time that iron-related compounds are important biomarkers that can predict malignant transformation with high sensitivity and specificity for women with endometriosis.
博士（医学）・乙第1367号・平成27年11月27日
Copyright ©2015 IOS Press All rights reserved.
The definitive version is available at " http://dx.doi.org/10.3233/CBM-150484 "
identifier:Cancer biomarkers Vol.15 No.4 p.493-499 (2015.06)
identifier:15740153
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3105
identifier:Cancer biomarkers, 15(4): 493-499
DOIinfo:doi/10.3233/CBM-150484
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