The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer

• 資料種別: 博士論文
• タイトル: The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer
• 著者・編者: Kawaguchi, Gen
• 出版事項: 新潟大学
• 出版年月日等: 2015-09-24
• 出版年（W3CDTF）: 2015-09-24
• 並列タイトル等: The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer; 表在型食道癌に対する内視鏡的粘膜下層剝離術後の化学放射線療法の有用性
• 授与機関名: 新潟大学
• 授与年月日: 2015-09-24
• 授与年月日（W3CDTF）: 2015-09-24
• 報告番号: 甲第4059号
• 学位: 博士（医学）
• 博論授与番号: 甲第4059号
• 本文の言語コード: eng
• 件名標目: Superficial esophageal cancer; Endoscopic submucosal dissection; Chemoradiotherapy; Combination; Pericardial effusion
• 一般注記: Background: To evaluate the risks and benefits of endoscopic submucosal dissection (ESD) in addition to chemoradiotherapy (CRT) for the treatment of superficial esophageal squamous cell carcinoma (SESCC). Methods and materials: We retrospectively reviewed the treatment outcomes of 47 patients with SESCC treated between October 2000 and December 2011. Sixteen patients with invasion into the submucosal layer (T1b) or the muscularis mucosa (m3) with positive vascular invasion were treated with CRT after ESD\ (ESD-CRT group). The lymph node area was irradiated to a total dose of 40–44 Gy and a boost radiation was administered if PET-positive lymph nodes or positive margins were observed. The remaining 31 patients received definitive CRT only (dCRT group). Results: The radiation field was significantly larger in the ESD-CRT group; the "long T" was used in 11 patients (35.4%) in the dCRT group and 15 (93.7%) in the ESD-CRT group (p = 0.0001). The total radiation dose was smaller in the ESD-CRT group; 40 Gy was used in 10 patients (62.5%) in the ESD-CRT group and all but one patient in the dCRT group received ≥60 Gy (p = 0.00001). The 3-year overall survival rates in the dCRT and ESD-CRT groups were 63.2% and 90.0% respectively (p = 0.118). Recurrence developed in nine patients (29.0%) in the dCRT group and one (6.3%) in the ESD-CRT group. Local recurrence was observed in six patients (19%) in the dCRT group and none in the ESD-CRT-group (p = 0.029). Pericardial effusion (≥Grade 3) occurred in three patients (9.7%) in the dCRT group and none in the ESD-CRT group. Conclusions: ESD followed by CRT is an effective and safe approach for SESCC at m3 or T1b. This combination of ESD and CRT improves the local control rate, and it could decrease the number of cardiac toxicities due to a radiation-dose reduction relative to CRT alone.; 学位の種類: 博士（医学）. 報告番号: 甲第4059号. 学位記番号: 新大院博（医）甲第648号. 学位授与年月日: 平成27年9月24日; Radiation Oncology. 2015, 10, 31.; 新大院博（医）甲第648号; 元資料の権利情報 : Copyright(C) 2015 Kawaguchi et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.; 開始ページ : 1; 終了ページ : 7
• DOI: info:doi/10.1186/s13014-015-0337-4; https://doi.org/info:doi/10.1186/s13014-015-0337-4
• 国立国会図書館永続的識別子: info:ndljp/pid/9577840; https://dl.ndl.go.jp/pid/9577840
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-01-05T14:58:43+09:00
• 作成日（W3CDTF）: 2019-08-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10191/35551
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp