Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients. 8

• 資料種別: 博士論文
• ISSN: 1340-3478
• タイトル: Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients.
• 巻次・部編番号: 22 8
• 著者・編者: OHUCHI, Masatsugu
• 著者標目: OHUCHI, Masatsugu
• 出版事項: 日本動脈硬化学会
• 出版年月日等: 2015-02-03
• 出版年（W3CDTF）: 2015-02-03
• タイトル（掲載誌）: Journal of atherosclerosis and thrombosis
• 授与機関名: 滋賀医科大学
• 授与年月日: 2015-09-09
• 授与年月日（W3CDTF）: 2015-09-09
• 報告番号: 乙第421号
• 学位: 博士（医学）
• 博論授与番号: 乙第421号
• 本文の言語コード: eng
• 件名標目: Microparticle; The Japanese Association for Acute Medicine Disseminated Intravascular Coagulopathy Score; Acute Physiology and Chronic Health Evaluation II Score; Sequential Organ Failure Assessment Score; Mortality
• 対象利用者: 一般
• 一般注記: Aim:The role of platelet-derived microparticles (PDMPs) in the crosstalk between coagulopathy and inflammation in critically ill patients remains unclear. The aim of this cohort observational study was to investigate the associations between the PDMP levels and hospital mortality or disseminated intravascular coagulopathy (DIC).; Methods:This study included 119 patients who were admitted to the ICU. The PDMP levels were measured using an enzyme-linked immunosorbent assay three times a week, for a total of 372 samples. We calculated the maximum (max) PDMP value, max PDMP/platelet (PDMP/Plts) ratio (converted to the PDMP levels per 10(4) platelets) and nadir platelet count during the ICU stay. Baseline patient data and scores, including the Japanese Association for Acute Medicine (JAAM) DIC score, were collected, and potential predictors were analyzed for possible associations with hospital mortality.; Results:The max PDMP/Plts ratio was significantly different comparing the survivors (n=98: median, 2.54) and non-survivors (n=21: median 17.59; p＜0.001). There was a weak but statistically significant negative correlation between the max PDMP level and nadir platelet count (r=-0.332, p＜0.001). The max PDMP level and max PDMP/Plts ratio were higher in the DIC group (81.48 and 9.27, respectively) than in the non-DIC group (34.88 and 2.35, p=0.001 and p＜0.001, respectively). The max PDMP/Plts ratio was the only variable found to be independently associated with hospital mortality according to a multivariate logistic regression analysis.; Conclusions:PDMPs are involved in the development of DIC but are not related to hospital mortality. There is a good association between the PDMP/Plts ratio and hospital mortality and/or DIC in critically ill patients.; Thesis or Dissertation; 平成27年度; 10.5551/jat.29439; J-STAGE
• DOI: info:doi/10.5551/jat.29439; https://doi.org/info:doi/10.5551/jat.29439
• 国立国会図書館永続的識別子: info:ndljp/pid/9768065; https://dl.ndl.go.jp/pid/9768065
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-02-01T21:19:47+09:00
• 作成日（W3CDTF）: 2017-02-17
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 原資料（URI）: https://dx.doi.org/10.5551/jat.29439
• 掲載誌（URI）: http://hdl.handle.net/10422/11111; https://shiga-med.repo.nii.ac.jp/records/1380
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2017-07-03 再収集

2023-07-18 再収集