Characterizations of the α₁-adrenoceptor subtypes mediating contractions of the human internal anal sphincter.

• 資料種別: 博士論文
• ISSN: 1347-8613
• タイトル: Characterizations of the α₁-adrenoceptor subtypes mediating contractions of the human internal anal sphincter.
• 巻次・部編番号: 127 4
• 著者・編者: Owaki, Hiroyuki; Sadahiro, Sotaro; Takaki, Miyako; 大脇, 浩幸; 貞廣, 荘太郎; 高木, 都
• 著者標目: Owaki, Hiroyuki; Sadahiro, Sotaro; Takaki, Miyako; 大脇, 浩幸; 貞廣, 荘太郎; 高木, 都
• 出版事項: Elsevier
• 出版年月日等: 2015-04; 127 4
• 出版年（W3CDTF）: 2015-04
• 並列タイトル等: ヒト内肛門括約筋収縮に寄与するアドレナリンα₁受容体サブタイプの解明
• タイトル（掲載誌）: Journal of pharmacological sciences
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2016-03-15
• 授与年月日（W3CDTF）: 2016-03-15
• 報告番号: 乙第1372号
• 学位: 博士（医学）
• 博論授与番号: 乙第1372号
• 本文の言語コード: eng
• 件名標目: Human internal anal sphincter; α₁-adrenoceptor; Fecal incontinence; Age-related response change; Comparison with inferior mesenteric artery; As a predictor of systemic arterial pressure
• 対象利用者: 一般
• 一般注記: type:Thesis; Human internal anal sphincter (IAS) is contracted by α₁-adrenoceptor stimulation and thus α₁-adrenoceptor agonists may be useful in treating fecal incontinence. This study characterizes the contribution of α₁-adrenoceptor subtypes in contraction of human IAS and to investigate the age-related risk of patients with fecal incontinence. IAS and inferior mesenteric artery (IMA), as a predictor of systemic arterial pressure, were obtained from 11 patients. Both muscle strips were assessed by isometric-contraction experiments using phenylephrine, further in IAS, in the presence of various subtype selective α₁-adrenoceptor antagonists. Immunohistochemistry and gene expression studies were performed in the same samples. The mean pEC₅₀ values with SEM of phenylephrine in IAS (6.30 ± 0.13) were higher than those of IMA (5.60 ± 0.10). Furthermore, the age-related pEC₅₀ change of IAS was observed between age <70 and ≥70 (6.58 ± 0.13 and 6.07 ± 0.16, respectively (P < 0.05)). In IAS, rightward shift of the concentration–response curves of phenylephrine was observed with three α₁-adrenoceptor antagonists. Each pKв value of silodosin, BMY-7378 and prazosin was 9.36 ± 0.53, 7.28 ± 0.20 and 8.89 ± 0.12, respectively. These pKв values and gene expression studies indicated that α₁ᴀ-adrenoceptor subtypes predominantly contributed to human IAS contraction.; 博士（医学）・乙第1372号・平成28年3月15日; © 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese PharmacologicalSociety. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).; identifier:Journal of pharmacological sciences Vol.127 No.4 p.424-429(2015.04); identifier:13478613; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3193; identifier:Journal of pharmacological sciences, 127(4): 424-429
• DOI: info:doi/10.1016/j.jphs.2015.02.016; https://doi.org/info:doi/10.1016/j.jphs.2015.02.016
• 国立国会図書館永続的識別子: info:ndljp/pid/9969035; https://dl.ndl.go.jp/pid/9969035
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-05-01T16:38:40+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3193
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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