Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model

• 資料種別: 博士論文
• ISSN: 1343-1420
• タイトル: Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model
• 巻次・部編番号: 61 1-2
• 著者・編者: Takechi, Hirokazu; Mawatari, Kazuaki; Harada, Nagakatsu; Takahashi, Akira; Nakaya, Yutaka; Asakura, Megumi; Nakahashi, Mutsumi; Takizawa, Hiromitsu; Goto, Masakazu; Nishino, Takeshi; Minato, Takuya; Furukita, Yoshihito; Yamamoto, Yota; Yuasa, Yasuhiro; Yamai, Hiromichi; Yoshida, Takahiro; Seike, Junichi; Tangoku, Akira
• 著者標目: Takechi, Hirokazu; Mawatari, Kazuaki; Harada, Nagakatsu; Takahashi, Akira; Nakaya, Yutaka; Asakura, Megumi; Nakahashi, Mutsumi; Takizawa, Hiromitsu; Goto, Masakazu; Nishino, Takeshi; Minato, Takuya; Furukita, Yoshihito; Yamamoto, Yota; Yuasa, Yasuhiro; Yamai, Hiromichi; Yoshida, Takahiro; Seike, Junichi; Tangoku, Akira
• 出版年月日等: 2014-02
• 出版年（W3CDTF）: 2014-02
• 並列タイトル等: グルタミンは抗癌剤起因性腸炎モデルラットの小腸粘膜を保護する; Glutamine protects small intestinal mucosa
• タイトル（掲載誌）: The journal of medical investigation : JMI
• 授与機関名: 徳島大学
• 授与年月日: 2014-03-19
• 授与年月日（W3CDTF）: 2014-03-19
• 報告番号: 甲第2742号
• 学位: 博士（医学）
• 博論授与番号: 甲第2742号
• 本文の言語コード: eng
• 件名標目: glutamine; gastrointestinal toxity; anticancer drug; diamine oxidase; IgA
• 対象利用者: 一般
• 一般注記: Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO[○R]) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.
• DOI: info:doi/10.2152/jmi.61.59; https://doi.org/info:doi/10.2152/jmi.61.59
• 国立国会図書館永続的識別子: info:ndljp/pid/9984261; https://dl.ndl.go.jp/pid/9984261
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-06-03T01:05:16+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/109521
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2019-09-09 再収集