Fucoxanthinol, Metabolite of Fucoxanthin, Improves Obesity-Induced Inflammation in Adipocyte Cells

• 資料種別: 記事
• タイトル: Fucoxanthinol, Metabolite of Fucoxanthin, Improves Obesity-Induced Inflammation in Adipocyte Cells
• 著者標目: Hayato Maeda; https://orcid.org/0000-0002-8546-6250; Shogo Kanno; Mei Kodate; Masashi Hosokawa; https://orcid.org/0000-0003-1755-3173; Kazuo Miyashita
• 出版年月日等: 2015-08-04
• 出版年（W3CDTF）: 2015-08-04
• タイトル（掲載誌）: Marine Drugs
• 巻号年月日等（掲載誌）: 13 8
• 掲載巻: 13
• 掲載号: 8
• 掲載ページ: 4799-4813
• 掲載年月日（W3CDTF）: 2015-08-04
• 出版事項（掲載誌）: MDPI AG
• 件名標目: Blood Glucose; obesity; QH301-705.5; Adipose Tissue, White; fucoxanthinol; Xanthophylls; adipocyte; Weight Gain; Article; fucoxanthin; Cell Line; Diabetes Mellitus, Experimental; Mice; 3T3-L1 Cells; Adipocytes; Animals; Obesity; RNA, Messenger; Biology (General); Chemokine CCL2; Inflammation; Tumor Necrosis Factor-alpha; Macrophages; beta Carotene; Diet; Disease Models, Animal; inflammation; Insulin Resistance
• 対象利用者: 一般
• 標準番号（その他）: PMID : 26248075
• DOI: 10.3390/md13084799
• 作成日（W3CDTF）: 2015-08-05
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: https://creativecommons.org/licenses/by/4.0/
• 関連情報（URI）: https://www.mdpi.com/1660-3397/13/8/4799/pdf
• 参照: Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells; https://cir.nii.ac.jp/crid/1360285711833868416; Effects of Z-Isomerization on the Bioavailability and Functionality of Carotenoids: A Review; https://cir.nii.ac.jp/crid/1360285715326597632; Anti-Oxidant and Fucoxanthin Contents of Brown Alga Ishimozuku (Sphaerotrichia divaricata) from the West Coast of Aomori, Japan; https://cir.nii.ac.jp/crid/1360848664433636736; The Suppressive Effect of a Marine Carotenoid, Fucoxanthin, on Mouse Ear Swelling through Regulation of Activities and mRNA Expression of Inflammation-associated Enzymes; https://cir.nii.ac.jp/crid/1390001204458723584
• 参照: Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice; https://cir.nii.ac.jp/crid/1050001202675060864; The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice; https://cir.nii.ac.jp/crid/1050575520348369280; Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus; https://cir.nii.ac.jp/crid/1360011143612978560; Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells; https://cir.nii.ac.jp/crid/1360011146003492736; Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues; https://cir.nii.ac.jp/crid/1360292619113046016; Obesity Wars; https://cir.nii.ac.jp/crid/1360292619268637184; Radical Scavenging and Singlet Oxygen Quenching Activity of Marine Carotenoid Fucoxanthin and Its Metabolites; https://cir.nii.ac.jp/crid/1360292619904094080; Anti-Obesity Activity of the Marine Carotenoid Fucoxanthin; https://cir.nii.ac.jp/crid/1360292620235967872; Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model; https://cir.nii.ac.jp/crid/1360292621466521600; AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet; https://cir.nii.ac.jp/crid/1360574093772589824; Petalonia binghamiae Extract and Its Constituent Fucoxanthin Ameliorate High-Fat Diet-Induced Obesity by Activating AMP-Activated Protein Kinase; https://cir.nii.ac.jp/crid/1360574095186516096; Increased oxidative stress in obesity and its impact on metabolic syndrome; https://cir.nii.ac.jp/crid/1360574095394068992; β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-α; https://cir.nii.ac.jp/crid/1360855568529194496; Dietary Combination of Fucoxanthin and Fish Oil Attenuates the Weight Gain of White Adipose Tissue and Decreases Blood Glucose in Obese/Diabetic KK-<i>A^y</i> Mice; https://cir.nii.ac.jp/crid/1360855569478572800; Molecular Mechanism of Metabolic Syndrome X: Contribution of Adipocytokines · Adipocyte‐derived Bioactive Substances; https://cir.nii.ac.jp/crid/1360855570220651136; Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.; https://cir.nii.ac.jp/crid/1361137043579892736; Fucoxanthin, a Marine Carotenoid Present in Brown Seaweeds and Diatoms: Metabolism and Bioactivities Relevant to Human Health; https://cir.nii.ac.jp/crid/1361137044417181696; N-acetylcysteine attenuates TNF-α induced changes in secretion of interleukin-6, plasminogen activator inhibitor-1 and adiponectin from 3T3-L1 adipocytes; https://cir.nii.ac.jp/crid/1361137045716451456; Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome; https://cir.nii.ac.jp/crid/1361418519295064832; BIOTRANSFORMATION OF FUCOXANTHINOL INTO AMAROUCIAXANTHIN A IN MICE AND HEPG2 CELLS: FORMATION AND CYTOTOXICITY OF FUCOXANTHIN METABOLITES; https://cir.nii.ac.jp/crid/1361699995961778816; A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes; https://cir.nii.ac.jp/crid/1362262944689703296; Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo; https://cir.nii.ac.jp/crid/1362262944736222080; TLR4 links innate immunity and fatty acid–induced insulin resistance; https://cir.nii.ac.jp/crid/1362262944779427328; The effects of Xanthigen^™in the weight management of obese premenopausal women with non‐alcoholic fatty liver disease and normal liver fat; https://cir.nii.ac.jp/crid/1362262946101011200; Paprika Pigments Attenuate Obesity-Induced Inflammation in 3T3-L1 Adipocytes; https://cir.nii.ac.jp/crid/1362825895412445184; Brown and beige fat: development, function and therapeutic potential; https://cir.nii.ac.jp/crid/1362825896005073536; Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages; https://cir.nii.ac.jp/crid/1363107368727430528; Obesity is associated with macrophage accumulation in adipose tissue; https://cir.nii.ac.jp/crid/1363107368959314432; Oxidative stress and metabolic syndrome; https://cir.nii.ac.jp/crid/1363107369724899584; Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-A mice; https://cir.nii.ac.jp/crid/1363388845806241152; MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity; https://cir.nii.ac.jp/crid/1363670320124133504; Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance; https://cir.nii.ac.jp/crid/1363670320505503488; Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice; https://cir.nii.ac.jp/crid/1364233268316910720; Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome; https://cir.nii.ac.jp/crid/1364233268564874112; Protondonative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl(DPPH); https://cir.nii.ac.jp/crid/1370002220682292743; Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells; https://cir.nii.ac.jp/crid/1370863720263167616; A New Sulfonated Tetrazolium Salt That Produces a Highly Water-Soluble Formazan Dye.; https://cir.nii.ac.jp/crid/1390001204161142784; Nuclear Receptors as Targets for Drug Development: Molecular Mechanisms for Regulation of Obesity and Insulin Resistance by Peroxisome Proliferator-Activated Receptor γ, CREB-Binding Protein, and Adiponectin; https://cir.nii.ac.jp/crid/1390001205176135424
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja

• 要約等: <jats:p>Fucoxanthin (Fx) is a marine carotenoid found in edible brown seaweeds. We previously reported that dietary Fx metabolite into fucoxanthinol ...