Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease

• 資料種別: 記事
• タイトル: Humanized anti-IL-26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease
• 著者標目: Ryo Hatano; https://orcid.org/0000-0002-2727-7275; Takumi Itoh; https://orcid.org/0000-0002-6535-1042; Haruna Otsuka; Harumi Saeki; Ayako Yamamoto; Dan Song; Yuki Shirakawa; Satoshi Iyama; Tsutomu Sato; https://orcid.org/0000-0003-2712-2713; Noriaki Iwao; Norihiro Harada; https://orcid.org/0000-0002-0962-5731; Thomas M. Aune; Nam H. Dang; Yutaro Kaneko; Taketo Yamada; Chikao Morimoto; Kei Ohnuma
• 出版年月日等: 2022-12
• 出版年（W3CDTF）: 2022-12
• タイトル（掲載誌）: American Journal of Transplantation
• 巻号年月日等（掲載誌）: 22 12
• 掲載巻: 22
• 掲載号: 12
• 掲載ページ: 2804-2820
• 掲載年月日（W3CDTF）: 2022-12
• ISSN（掲載誌）: 16006135
• 出版事項（掲載誌）: Elsevier BV
• 件名標目: Pharmacology (medical); Transplantation; Immunology and Allergy
• 対象利用者: 一般
• 標準番号（その他）: PMID : 35997569
• DOI: 10.1111/ajt.17178
• 作成日（W3CDTF）: 2022-08-23
• 著作権情報: https://www.elsevier.com/tdm/userlicense/1.0/
• 関連情報（URI）: https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajt.17178; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ajt.17178; https://api.elsevier.com/content/article/PII:S1600613523000333?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S1600613523000333?httpAccept=text/plain
• 参照: Anti-glomerular Basement Membrane Disease Concomitant with MPO-ANCA Positivity Concurrent with High Serum Levels of Interleukin-26 Following Coronavirus Disease 2019 Vaccination; https://cir.nii.ac.jp/crid/1390858608252789120
• 参照: Regulation of Pulmonary Graft-versus-Host Disease by IL-26+CD26+CD4 T Lymphocytes; https://cir.nii.ac.jp/crid/1360002220913105920; Biological Effects of IL-26 on T Cell–Mediated Skin Inflammation, Including Psoriasis; https://cir.nii.ac.jp/crid/1360004232284131200; In vitro–differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations; https://cir.nii.ac.jp/crid/1360011144890727680; IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells; https://cir.nii.ac.jp/crid/1360011145493022592; Interleukin-26: An IL-10-related cytokine produced by Th17 cells; https://cir.nii.ac.jp/crid/1360011145501526528; Interleukin-26 Production in Human Primary Bronchial Epithelial Cells in Response to Viral Stimulation: Modulation by Th17 cytokines; https://cir.nii.ac.jp/crid/1360011146420058240; IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells; https://cir.nii.ac.jp/crid/1360013168787580288; Strategies for Enhancing and Preserving Anti-leukemia Effects Without Aggravating Graft-Versus-Host Disease; https://cir.nii.ac.jp/crid/1360017285921692800; Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation; https://cir.nii.ac.jp/crid/1360017286456226432; Implications of Resident Memory T Cells for Transplantation; https://cir.nii.ac.jp/crid/1360017289333132544; Single-cell atlas of colonic CD8+ T cells in ulcerative colitis; https://cir.nii.ac.jp/crid/1360290617863298432; IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation; https://cir.nii.ac.jp/crid/1360292620026196352; Regulatory roles of IL-17 and IL-17F in G-CSF production by lung microvascular endothelial cells stimulated with IL-1β and/or TNF-α; https://cir.nii.ac.jp/crid/1360292620957896576; IL-26 is overexpressed in chronically HCV-infected patients and enhances TRAIL-mediated cytotoxicity and interferon production by human NK cells; https://cir.nii.ac.jp/crid/1360292621437723776; Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies; https://cir.nii.ac.jp/crid/1360294645216656640; Activity and components of the granulocyte colony‐stimulating factor pathway in hidradenitis suppurativa*; https://cir.nii.ac.jp/crid/1360298762044930688; The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases; https://cir.nii.ac.jp/crid/1360574094892207360; Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element; https://cir.nii.ac.jp/crid/1360574094926733056; IL-6 Cooperates with G-CSF To Induce Protumor Function of Neutrophils in Bone Marrow by Enhancing STAT3 Activation; https://cir.nii.ac.jp/crid/1360580238057773568; A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4+ or CD8+ T Cells Using Immunodeficient NOG Mice; https://cir.nii.ac.jp/crid/1360846643065180544; Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis; https://cir.nii.ac.jp/crid/1360849944149884160; Human neutrophils in the saga of cellular heterogeneity: insights and open questions; https://cir.nii.ac.jp/crid/1361137043759323520; G-CSF: A key regulator of neutrophil production, but that's not all!; https://cir.nii.ac.jp/crid/1361137044358395776; Mechanisms of fibrosis: therapeutic translation for fibrotic disease; https://cir.nii.ac.jp/crid/1361137045135705216; The T-cell Lymphokine Interleukin-26 Targets Epithelial Cells through the Interleukin-20 Receptor 1 and Interleukin-10 Receptor 2 Chains; https://cir.nii.ac.jp/crid/1361418519198617856; Revealing Tumor Immunity after Hematopoietic Stem Cell Transplantation; https://cir.nii.ac.jp/crid/1361418519241334656; TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26; https://cir.nii.ac.jp/crid/1361418519472225152; Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling; https://cir.nii.ac.jp/crid/1361418519891683072; IL-26 Confers Proinflammatory Properties to Extracellular DNA; https://cir.nii.ac.jp/crid/1361418521396675328; The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo; https://cir.nii.ac.jp/crid/1361981468382519936; The family of IL-10-related cytokines and their receptors: related, but to what extent?; https://cir.nii.ac.jp/crid/1361981471465842560; Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors; https://cir.nii.ac.jp/crid/1362262946454941056; Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells; https://cir.nii.ac.jp/crid/1362544418357956224; Developmental pathways in the pathogenesis of lung fibrosis; https://cir.nii.ac.jp/crid/1362544418466739328; Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage; https://cir.nii.ac.jp/crid/1362544418942964608; Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?; https://cir.nii.ac.jp/crid/1362825895357725952; Fibrosis: from mechanisms to medicines; https://cir.nii.ac.jp/crid/1362825895510362240; T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.; https://cir.nii.ac.jp/crid/1363107369040118272; Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization; https://cir.nii.ac.jp/crid/1363107370022667392; Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ; https://cir.nii.ac.jp/crid/1363388844311997056; Hematopoietic Stem-Cell Transplantation; https://cir.nii.ac.jp/crid/1363951793494229248; Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset; https://cir.nii.ac.jp/crid/1363951794532247552; Interleukin-26 in Antibacterial Host Defense of Human Lungs. Effects on Neutrophil Mobilization; https://cir.nii.ac.jp/crid/1363951794842010496; Distal Regions of the Human <i>IFNG</i> Locus Direct Cell Type-Specific Expression; https://cir.nii.ac.jp/crid/1364233270729996160; IL-26 contributes to host defense against intracellular bacteria; https://cir.nii.ac.jp/crid/1364233270882688640; The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer; https://cir.nii.ac.jp/crid/1370298757187355796; Effects of recombinant human granulocyte colony-stimulating factor administration on neutrophil phenotype and functions; https://cir.nii.ac.jp/crid/1370298757187355798
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja

• 要約等: IL-26 is a Th17 cytokine, with its gene being absent in rodents. To characterize the in vivo immunological effects of IL-26 in chronic systemic inflam...