記事
FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5
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CiNii Research
FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5
- 資料種別
- 記事
- 著者
- Kengo Takedaほか
- 出版者
- MDPI AG
- 出版年
- 2024-03-26
- 資料形態
- デジタル
- 掲載誌名
- International Journal of Molecular Sciences 25 7
- 掲載ページ
- p.3693-
資料詳細
要約等：
- <jats:p>Chronic myeloid leukemia (CML) is induced by the expression of the fused tyrosine kinase BCR-ABL, which is caused by a chromosomal translocati...
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デジタル
- 資料種別
- 記事
- 著者標目
- 出版年月日等
- 2024-03-26
- 出版年（W3CDTF）
- 2024-03-26
- タイトル（掲載誌）
- International Journal of Molecular Sciences
- 巻号年月日等（掲載誌）
- 25 7
- 掲載巻
- 25
- 掲載号
- 7
- 掲載ページ
- 3693-
- 掲載年月日（W3CDTF）
- 2024-03-26
- 出版事項（掲載誌）
- MDPI AG
- 件名標目
- 対象利用者
- 一般
- DOI
- 10.3390/ijms25073693
- 作成日（W3CDTF）
- 2024-03-26
- オンライン閲覧公開範囲
- インターネット公開
- 著作権情報
- https://creativecommons.org/licenses/by/4.0/
- 参照
- Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisisSpotlight on ponatinib in the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia: patient selection and perspectivesBCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlationsAnalysis of the RNA Helicase p68 (Ddx5) as a Transcriptional RegulatorWnt/β-catenin signaling and p68 conjointly regulate CHIP in colorectal carcinomaAbsence of the human retinoblastoma gene product in the megakaryoblastic crisis of chronic myelogenous leukemiaVerbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemiaEndogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1Ponatinib-induced cardiotoxicity: delineating the signalling mechanisms and potential rescue strategiesChromosome 17 Abnormalities and Inactivation of the P53 Gene in Chronic Myeloid Leukemia and Their Prognostic SignificanceThe RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancersThree Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced TumorigenesisTaxodione induces apoptosis in BCR-ABL-positive cells through ROS generationPhosphorylations of DEAD Box p68 RNA Helicase Are Associated with Cancer Development and Cell ProliferationTyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.The Microprocessor complex mediates the genesis of microRNAsPotent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivativesP68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from β-CateninThe allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1Apoptosis: biochemical aspects and clinical implicationsFL118, acting as a ‘molecular glue degrader’, binds to, dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c‐Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacyA helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survivalDDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer CellsDEAD-box protein p68 is regulated by β-catenin/transcription factor 4 to maintain a positive feedback loop in control of breast cancer progressionKorean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM‐5 CellsRoles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignanciesp68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF- B transcription factor p50Indirect p53-dependent transcriptional repression of<i>Survivin, CDC25C,</i>and<i>PLK1</i>genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complexMolecular Mechanisms in the Evolution of Chronic Myelocytic LeukemiaFunctional Cooperation among Ras, STAT5, and Phosphatidylinositol 3-Kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 CellsPUMA, a Novel Proapoptotic Gene, Is Induced by p53Identification of <scp>DDX5</scp> as an indispensable activator of the glucocorticoid receptor in adipocyte differentiationThe lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancerThe Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapyThe indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutantp68 RNA Helicase Is an Essential Human Splicing Factor That Acts at the U1 snRNA-5′ Splice Site DuplexAP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based ResistanceTranscriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2APUMA Induces the Rapid Apoptosis of Colorectal Cancer CellsSTAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F MutantComparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)–based mutagenesis screen: high efficacy of drug combinationsDasatinib: A tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome—positive acute lymphoblastic leukemiaDasatinib in Imatinib-Resistant Philadelphia Chromosome–Positive LeukemiasCooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cellsBCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous LeukemiaBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.WAF1, a potential mediator of p53 tumor suppressionMutational inactivation of the p53 gene in the human erythroid leukemic K562 cell lineA cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemiaSTAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen speciesThe DEAD-box protein family of RNA helicasesEffects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cellsA Novel Small Molecule FL118 That Selectively Inhibits Survivin, Mcl-1, XIAP and cIAP2 in a p53-Independent Manner, Shows Superior Antitumor ActivityA New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa StainingSignal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for LeukemogenesisMolecular and chromosomal mechanisms of resistance to imatinib (STI571) therapyClinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or AmplificationControl of apoptosis and mitotic spindle checkpoint by survivinRedundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferationSignaling Networks Associated with BCR–ABL–Dependent TransformationCamptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cellsSingle-cell analysis of K562 cells: An imatinib-resistant subpopulation is adherent and has upregulated expression of BCR-ABL mRNA and proteinEvolution of Therapies for Chronic Myelogenous LeukemiaOncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein family member SurvivinInactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cellsStructure of the Bcr-Abl oncoprotein oligomerization domainConstitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Crossref科学研究費助成事業データベース科学研究費助成事業データベース