THE CANINE CYP1A2 DEFICIENCY POLYMORPHISM DRAMATICALLY AFFECTS THE PHARMACOKINETICS OF 4-CYCLOHEXYL-1-ETHYL-7-METHYLPYRIDO[2,3-D]-PYRIMIDINE-2-(1H)-ONE (YM-64227), A PHOSPHODIESTERASE TYPE 4 INHIBITOR

• 資料種別: 記事
• タイトル: THE CANINE CYP1A2 DEFICIENCY POLYMORPHISM DRAMATICALLY AFFECTS THE PHARMACOKINETICS OF 4-CYCLOHEXYL-1-ETHYL-7-METHYLPYRIDO[2,3-D]-PYRIMIDINE-2-(1H)-ONE (YM-64227), A PHOSPHODIESTERASE TYPE 4 INHIBITOR
• 著者標目: Daisuke Tenmizu; Kiyoshi Noguchi; Hidetaka Kamimura; https://orcid.org/0000-0002-8371-7159; Hisakazu Ohtani; https://orcid.org/0000-0002-4089-9407; Yasufumi Sawada
• 出版年月日等: 2006-05
• 出版年（W3CDTF）: 2006-05
• タイトル（掲載誌）: Drug Metabolism and Disposition
• 巻号年月日等（掲載誌）: 34 5
• 掲載巻: 34
• 掲載号: 5
• 掲載ページ: 800-806
• 掲載年月日（W3CDTF）: 2006-05
• ISSN（掲載誌）: 00909556
• 出版事項（掲載誌）: Elsevier BV
• 件名標目: Male; Polymorphism, Genetic; Genotype; Phosphodiesterase Inhibitors; Administration, Oral; In Vitro Techniques; Cyclic Nucleotide Phosphodiesterases, Type 4; Dogs; Pyrimidines; 3',5'-Cyclic-AMP Phosphodiesterases; Cyclohexanes; Cytochrome P-450 CYP1A2; Injections, Intravenous; Microsomes, Liver; Animals; Biotransformation; Protein Binding
• 対象利用者: 一般
• 標準番号（その他）: PMID : 16473917
• DOI: 10.1124/dmd.105.008722
• 作成日（W3CDTF）: 2006-02-11
• 著作権情報: https://www.elsevier.com/tdm/userlicense/1.0/; https://www.elsevier.com/legal/tdmrep-license
• 関連情報（URI）: https://api.elsevier.com/content/article/PII:S009095562403486X?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S009095562403486X?httpAccept=text/plain; https://syndication.highwire.org/content/doi/10.1124/dmd.105.008722
• 参照: A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models; https://cir.nii.ac.jp/crid/1360302866855145088
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Crossref; https://www.crossref.org

• 要約等: In a previous study, it was shown that the novel canine single nucleotide polymorphism (SNP) CYP1A2 1117CT yields an inactive enzyme. In this study, t...