記事
The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin
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CiNii Research
The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin
- 資料種別
- 記事
- 著者
- Mei Nakagawaほか
- 出版者
- Portland Press Ltd.
- 出版年
- 2022-09-30
- 資料形態
- デジタル
- 掲載誌名
- Biochemical Journal 479 18
- 掲載ページ
- p.1999-2011
資料詳細
要約等：
- <jats:p>Destabilization of human transthyretin leads to its aggregation into amyloid fibrils, which causes a rare, progressive and fatal systemic diso...
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デジタル
- 資料種別
- 記事
- 出版年月日等
- 2022-09-30
- 出版年（W3CDTF）
- 2022-09-30
- タイトル（掲載誌）
- Biochemical Journal
- 巻号年月日等（掲載誌）
- 479 18
- 掲載巻
- 479
- 掲載号
- 18
- 掲載ページ
- 1999-2011
- 掲載年月日（W3CDTF）
- 2022-09-30
- ISSN（掲載誌）
- 02646021
- 出版事項（掲載誌）
- Portland Press Ltd.
- 対象利用者
- 一般
- DOI
- 10.1042/bcj20220203
- 作成日（W3CDTF）
- 2022-09-13
- 著作権情報
- http://creativecommons.org/licenses/by/2.0/
- 参照
- Evidence for Early Cytotoxic Aggregates in Transgenic Mice for Human Transthyretin Leu55ProTransthyretin Cardiac Amyloidosis in Older AmericansMutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5–15kDCrystal Structures of Human Transthyretin Complexed with GlabridinThe EMBL-EBI search and sequence analysis tools APIs in 2019Retinol-binding protein: the transport protein for vitamin A in human plasmaFibril in senile systemic amyloidosis is derived from normal transthyretin.Guideline of transthyretin-related hereditary amyloidosis for cliniciansGenetic and clinical characteristics of hereditary transthyretin amyloidosis in endemic and non-endemic areas: experience from a single-referral center in Japan<i>Coot</i>: model-building tools for molecular graphicsFluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine TScaling and assessment of data qualityRecent advances in transthyretin amyloidosis therapyA molecular mechanism for transthyretin amyloidogenesisEvolution of thyroid hormone distributor proteins in fishTransthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution<i>In vivo</i>stabilization of mutant human transthyretin in transgenic miceProteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesisTransthyretin: a multifaceted proteinThe V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosisHuman-Murine Transthyretin Heterotetramers Are Kinetically Stable and Non-amyloidogenicPartial denaturation of transthyretin is sufficient for amyloid fibril formation in vitroNative State Kinetic Stabilization as a Strategy To Ameliorate Protein Misfolding Diseases: A Focus on the Transthyretin AmyloidosesBiophysical Analyses of the Transthyretin Variants, Tyr114His and Tyr116Ser, Associated with Familial Amyloidotic Polyneuropathy<i>PHENIX</i>: a comprehensive Python-based system for macromolecular structure solutionEvolution of the Thyroid Hormone-Binding Protein, TransthyretinOBSERVATIONS CONCERNING THE BINDING OF THYROID HORMONES BY HUMAN SERUM PREALBUMIN*The Acid-Mediated Denaturation Pathway of Transthyretin Yields a Conformational Intermediate That Can Self-Assemble into AmyloidThe Most Pathogenic Transthyretin Variant, L55P, Forms Amyloid Fibrils under Acidic Conditions and Protofilaments under Physiological ConditionsTransthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity<i>Phaser</i>crystallographic softwarePRE-ALBUMIN: A THYROXINE-BINDING PROTEIN OF HUMAN PLASMA<i>iMOSFLM</i>: a new graphical interface for diffraction-image processing with<i>MOSFLM</i>Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascadeDimeric Transthyretin Variant Assembles into Spherical NeurotoxinsThe Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved DrugThree-state denaturation of α-lactalbumin by guanidine hydrochlorideCryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosisPrevention of Transthyretin Amyloid Disease by Changing Protein Misfolding EnergeticsInhibiting transthyretin amyloid fibril formation via protein stabilizationAmyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committeeTransthyretin Ile73Val is associated with familial amyloidotic polyneuropathy in a Bangladeshi family. Mutations in brief no. 158. Online
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Crossref科学研究費助成事業データベース