魚肝臓S9代謝反応における速度定数と遊離基質補正値を用いたアルキルフェノール類の生物濃縮倍率の予測精度向上

• 資料種別: 記事
• タイトル: 魚肝臓S9代謝反応における速度定数と遊離基質補正値を用いたアルキルフェノール類の生物濃縮倍率の予測精度向上
• 著者標目: 宮田 知代子; 的場 好英; 椋本 麻記子; 中川 好秋; 宮川 恒
• 出版年月日等: 2022-08-20
• 出版年（W3CDTF）: 2022-08-20
• タイトル（掲載誌）: 農薬誌
• 巻号年月日等（掲載誌）: 47 2
• 掲載巻: 47
• 掲載号: 2
• 掲載ページ: 31-39
• 掲載年月日（W3CDTF）: 2022-08-20
• ISSN（掲載誌）: 21870365
• 出版事項（掲載誌）: Pesticide Science Society of Japan
• 本文の言語コード: ja
• 件名標目: bioaccumulation; biotransformation; fish; liver; RT-S9; TG 319
• 対象利用者: 一般
• DOI: 10.1584/jpestics.w22-34
• 関連情報（URI）: https://www.jstage.jst.go.jp/article/jjpestics/47/2/47_W22-34/_pdf
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https://cir.nii.ac.jp/crid/1362544419653419648; Metabolic biotransformation half-lives in fish: QSAR modeling and consensus analysis; https://cir.nii.ac.jp/crid/1362544421140955392; Comparison of basal level metabolic enzyme activities of freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat; https://cir.nii.ac.jp/crid/1362825896276202496; Considerations and recent advances in QSAR models for cytochrome P450-mediated drug metabolism prediction; https://cir.nii.ac.jp/crid/1363670318360968448; Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates; https://cir.nii.ac.jp/crid/1363670319495561088; Novel Metabolic Pathways of p-n-Nonylphenol Catalyzed by Cytochrome P450 and Estrogen Receptor Binding Activity of New Metabolites; https://cir.nii.ac.jp/crid/1390282679475665024
• 連携機関・データベース: 国立情報学研究所 : CiNii Research
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org

• 要約等: <p>濃縮性評価に用いられているQSAR式では代謝速度が予測困難なアルキルフェノール類7化合物について，RT-S9による分解反応速度を測定した．フェニル基の近傍に<i>tert</i>-ブチル基が配置されている化合物では酸化・抱合化反応が起こり難く反応速度が遅かった．当該結果とRT-S9反応液中の化...