心嚢液吸引細胞診にて推定診断しえた原発性体腔液性リンパ腫(PEL)の1症例
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- Material Type
- 記事
- Publication Date
- 2001
- Publication Date (W3CDTF)
- 2001
- Periodical title
- 日臨細胞誌
- No. or year of volume/issue
- 40 3
- Volume
- 40
- Issue
- 3
- Pages
- 281-285
- Publication date of volume/issue (W3CDTF)
- 2001
- ISSN (Periodical Title)
- 03871193
- ISSN-L (Periodical Title)
- 03871193
- Publication (Periodical Title)
- The Japanese Society of Clinical Cytology
- Text Language Code
- ja
- Target Audience
- 一般
- DOI
- 10.5795/jjscc.40.281
- Related Material (URI)
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link CenterCrossrefCiNii ArticlesCiNii Articles
- NAID
- 13000375884910007682762
- Summary, etc.
- <B><I>Background</I>:</B> Primary effusion lymphomas (PEL) are very rare. We report a case of PEL and its cytological, immunocytochemical, and ultrastructural findings.<BR><B><I>Case</I>:</B> A 63-year-old man undergoing hemodyalysis due to diabetic nephropathy reported dull pain radiating from the right shoulder to the chest wall. Computed tomography.(CT) disclosed marked paricardial effusion. Atypical cells with a high N/C ratio demonstrated by aspiration cytology reacted positively with antibodies for EMA and CD 30 but were negative for L 26 and CD 15. No atypical cells were seen in peripheral blood or bone-marrow puncture material. CT and gallium scintigraphy showed no systemic lymph node swelling. Anti carcinogenic drugs were administered systemically together with pericardial effusion, but the man died 2 months after disease onset. An autopsy showed a 1.5×0.5 cm subcutaneous tumor in the chest wall, but no significant lymph node swelling.<BR><B><I>Conclusion</I>:</B> A man reporting pain radiating from the right showlder to the chest wall was found on autopsy to be suffering from primary effusion lymphoma.<B>背景:</B>体腔液原発の悪性リンパ腫はきわめてまれである. 心嚢液中に発生した原発性体腔液性リンパ腫 (PEL) の1症例を経験したのでその細胞像を中心に報告する.<BR><B>症例:</B>患者は63歳男性. 慢性腎不全のため, 透析中であった. 透析中に, 右肩から胸部へかけて鈍痛を訴え, 胸部CTでCTRが80%以上と著明な心嚢液貯留を認めた. 心嚢ドレナージ液から, 小リンパ球の2から3倍大の異型細胞が多数認められた.異型細胞は, 1~数個の明瞭な核小体を認め, 多核細胞や核分裂像も散見された. 免疫染色では, 異型細胞はCD30およびEMAが陽性, LCA, UCHL-1, L26およびCD15が陰性で, ALCLが考えられた. 末梢血および骨髄では明らかな異型細胞は認められず, 全身リンパ節を含めたほかの部位にも明らかな病変を認めず, 心嚢液原発と考えられた. その後, 胸水貯留が出現し, 胸水の細胞診より腫瘍細胞が認められ, 約2ヵ月の経過で死亡した.剖検時には, 肉眼的には左胸部の皮下に1.5×0.5cmの転移性腫瘤を認めたのみで, リンパ節腫大などの病変は認められなかった. 組織学的には, 胸部皮下腫瘤以外に, 数ヵ所に微小な腫瘍結節を認めたのみであった.<BR><B>結論:</B>体腔液原発の悪性リンパ腫の症例は少なく稀少症例と考えられ, その細胞像を中心に報告した.
- DOI
- 10.5795/jjscc.40.281
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE